Two-Stage Method for Reliable Routine Cancer Screening

Technology #34509

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Researchers
Michael Walter Rohr
Deborah A. Altomare, Ph.D.
Trina Angel Rudeski-Rohr
Patent Protection

Provisional Patent Application Filed

Key Points

  • Blood-based cancer screening test with secondary validation
  • Concept modeled closely after the widely used dexamethasone suppression test
  • Offers higher reliability, modularity, and the potential to be applied in multiple settings

Abstract

The University of Central Florida invention relates to a two-step, blood-based cancer screening test. The first step screens for elevated levels of Fibroblast Growth Factor 19 (FGF19) via a standard enzyme-linked immunosorbent assay (ELISA). Patients with elevated levels of FGF19 continue with a second/follow-up test using oral cholestyramine as a “suppression” drug to verify that the FGF19 is originating from cancer and not from the normal secretion site, the terminal ileum. Serum levels of FGF19 that remain elevated after cholestyramine treatment may be suggestive of cancer.