Improving Cancer Therapy by Silencing Stemness Genes

Technology #34329

Key Points

  • Invention targets “stemness” genes, NANOG/P8 and OCT4 in Glioblastoma Multiforme cancer stem cells
  • Causes cancer stem cells to become vulnerable to existing therapies
  • May improve delivery of shRNA using an exosomal delivery system

The University of Central Florida invention relates to methods for inhibiting the expression of the “stemness” genes, NANOG/P8 and OCT4 in Glioblastoma Multiforme cancer stem cells. Short hairpin RNAs (shRNAs) were specifically designed to inhibit the expression of NANOG/P8 or OCT4 and were delivered by lentiviral transduction. Exosomal delivery of the shRNAs is currently in development.