- Well-characterized cytoplasmic protein may increase the susceptibility of a cancer cell to an anti-cancer agent or radiation therapy
- Delivery of the protein may reduce the emergence of drug-resistant cancer cells
The University of Central Florida invention relates to the development of a combination therapy to increase the sensitivity of cancer cells to chemotherapy. The “sensitizing agent” is a small viral protein known as the V protein. As a feasibility study, expression of the V protein in tissue culture cells increased the sensitivity of cancer cells to a range of chemotherapeutic agents.
- May reduce the effective chemotherapy dose required to kill cancer cells
- Combination chemotherapy