Low-Cost Test for Distinguishing Between Real and Synthetic Urine

Technology #34002

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Edward Allan Ross, M.D.
External Link (med.ucf.edu)
Sudipta Seal, Ph.D.
External Link (www.cecs.ucf.edu)
Managed By
Brion Berman
Assistant Director 407.882.0342
Patent Protection

Provisional Patent Application Filed

Test for identifying fake urine when screening workers for illicit drugs

UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external labs to perform the rigorous, expensive testing needed to confirm that a urine sample is authentic. In contrast, the UCF technology could be used to create a rapid-screening test to verify a urine sample outside a lab (at a workplace, for example) and at less cost.

Technical Details

The novel method provides an approach for quickly distinguishing between real and synthetic urine. The approach includes a color-responsive assay, so that testing can be performed on a simple test strip. The color-responsive nanotechnology may be used to detect compounds, chemical moieties, and/or metabolites normally found in urine, but not in synthetic urine due to stability, half-life, metabolism or chemical complexity.

Partnering Opportunity

The research team is looking for partners to further develop the technology for commercialization.


  • Enables the creation of drug tests to easily check whether a urine sample is natural or synthetic
  • Provides methods for creating quick, inexpensive onsite testing (for example, at a work place)


  • Employer drug testing
  • Competitive sports drug testing