Customizable 3D Microelectrode Array with Tri-Modal Functionalities

Technology #2021-109

Key Points

  • A three-dimensional (3D) microelectrode array technology for obtaining in vitro data sets of electrical, optical and microfluidic markers from electrogenic cell constructs
  • 3D MEAs are the next generation interfaces for "organ-on-a-chip" in vitro modeling
  • Rapid neuronal spheroid attachment to the 3D microfluidic ports of the tri-modal 3D MEA has been demonstrated successfully

Abstract

The University of Central Florida invention is a polymer and metal-based microfabrication technology for 3D microelectrode arrays (3D MEAs). The device incorporates “tri-modal functionality” for obtaining simultaneous data sets comprising electrical, optical and microfluidic markers from a variety of electrogenic cellular constructs. 3D MEAs are the next-generation interfaces for “organ-on-a-chip” in vitro modeling of biological functions. Rapid neuronal spheroid attachment to the 3D microfluidic ports of the tri-modal 3D MEA has been demonstrated successfully.

Benefit

  • Simple design can be scaled appropriately for larger and customizable array configurations
  • Inexpensive
  • Allows for faster, more effective process development and device integration

Market Application

  • Micro-electromechanical systems
  • In vitro biological models