Healthcare » Therapeutics

Found 8 technologies within Therapeutics RSS ATOM

Targeting Oxidative Stress for Parkinson’s Disease Therapy

32897 – Adeno-Associated Virus (AAV) Vector-Mediated Knockdown of NADPH Oxidase1 (Nox1) Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the aggregation of α-synuclein proteins and the progressive loss of dopaminergic neurons. Oxidative stress is a major contributing factor in the pathogenesis of PD and has been linked to both α-synuclein aggregation and... Read More

Block diagram of the experiment used to determine the emission spectra of the samples

Technique for Tagging Therapeutically Relevant Compounds for Tracking and Evaluation Using Infrared Excitation Sources

31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

TEM image of dextran-coated (a) gold and (b) iron oxide nanoparticles according to an embodiment of the present invention; the TEM images show that the gold nanoparticles are spherical, whereas the iron oxide particles are rods

Nanoparticle-Mediated Methods for Antimicrobial Susceptibility Testing of Bacteria

31218 – Method of utilizing nanosensors to measure antimicrobial susceptibility of a microbe to current or potential antibiotics The identification and administration of an effective antimicrobial agent (antibiotic) is of the utmost importance in both the clinical and research settings. With the emergence of multidrug resistant bacterial strains, such as MRSA, identifying the most effective... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Non-Aqueous Amino Acid Production

32954 – The nutraceuticals, fodder, and laboratory industries require different standards and specifications for the amino acids and small peptide chains used. However, current methodology cannot produce these materials at the same time to meet these different standards and specifications because they are produced by aqueous acid hydrolysis or enzymatic hydrolysis. Additionally, these processes are... Read More