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32882 – New Marine-Based Compounds and Aurora Kinase Inhibitors May Effectively Combat Malaria UCF researchers have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs. The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial... Read More
32897 – Adeno-Associated Virus (AAV) Vector-Mediated Knockdown of NADPH Oxidase1 (Nox1) Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the aggregation of α-synuclein proteins and the progressive loss of dopaminergic neurons. Oxidative stress is a major contributing factor in the pathogenesis of PD and has been linked to both α-synuclein aggregation and... Read More
31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More
31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More
31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More
32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More
31218 – Method of utilizing nanosensors to measure antimicrobial susceptibility of a microbe to current or potential antibiotics The identification and administration of an effective antimicrobial agent (antibiotic) is of the utmost importance in both the clinical and research settings. With the emergence of multidrug resistant bacterial strains, such as MRSA, identifying the most effective... Read More
33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More
32954 – The nutraceuticals, fodder, and laboratory industries require different standards and specifications for the amino acids and small peptide chains used. However, current methodology cannot produce these materials at the same time to meet these different standards and specifications because they are produced by aqueous acid hydrolysis or enzymatic hydrolysis. Additionally, these processes are... Read More