Healthcare » Therapeutics

Found 17 technologies within Therapeutics RSS ATOM

CD25-Targeted IL-2 for Treating Viral Infections and Boosting Memory CD4 T Cell Formation

11577 – The University of Central Florida invention relates to the development of a new use for the interleukin‐2 (IL‐2) cytokine antibody complex, JES6 IL‐2C, for the treatment of acute respiratory viral infections. The IL‐2 antibody complex targets the IL‐2 to subsets of immune cells based on their expression of a specific subunit of the IL‐2 receptor. Mice infected with the influenza A... Read More

Combination Drug Treatment to Increase Neurogenesis for Neurological Disorders

11616 – The University of Central Florida invention relates to a combination therapy to promote neuroregeneration consisting of 1) MS-818 to increase endogenous neural stem cells and 2) non-steroidal anti-inflammatory drugs to suppress inflammation

Targeting Cancer Stem Cells with RNAi

34329 – Researchers at the University of Central Florida are developing RNA interference (RNAi)-based therapies for increasing the sensitivity of cancer stem cells to chemotherapy. Cancer stem cells are a specialized subset of tumor cells that are often resistant to cancer therapy. This technology targets the expression of the embryonic stem cell genes NANOG or OCT4 which are expressed in... Read More

Direct Reprogramming of Mesenchymal Stems Cells to Neural Stem Cell-Like Cells

34445 – Researchers at the University of Central Florida have developed a xeno-free and transgene-free method for reprogramming mesenchymal stem cells to neural stem cell-like cells. Neural stem cells are difficult to obtain for therapeutic use due to their location in the brain. As an alternative, multipotent mesenchymal stem cells are a potential source of neural stem cells, but must... Read More

Polyamine Transport Inhibitors as Antiviral Agents

34459 – Researchers at the University of Central Florida and Boston University are developing polyamine transport inhibitors for use as antiviral compounds. Polyamines are required for a variety of viral processes including replication, protein synthesis, and virus-host interactions. Many viruses, including coronaviruses, have been shown to be sensitive to polyamine depletion. While... Read More

Fungus-Derived Compounds to Fight Drug-Resistant Malaria

34250 – Researchers at the University of Central Florida and the University of Oklahoma have identified fungus-derived compounds for developing treatments against drug-resistant species of Plasmodium. Compounds collected from a large library of diverse fungi (including pure compounds and extracts) may enable scientists to target new cellular structures of malaria-causing parasites such as... Read More

The UCF invention delivers iron to targeted tumor cells to enable ferroptosis-assisted chemodynamic therapy. Image reprinted with permission from Molecular Pharmaceutics 2019, 16, 4852−4866, DOI: 10.1021/acs.molpharmaceut.9b00737. American Chemical Society.

Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy

34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More

Diagram of a MINI system for wireless neural recordings. The 1000-ch system on a silicon die consists of a pillar electrode array, embedded integrated circuits for signal amplification and processing, and backplane planar coils and capacitors for wireless telemetry and power.

Neural Interface System

34017 – New approach to building scalable brain-machine interface systems may enable widespread use of wireless, remotely-powered neural interface implants in patients needing prostheses. Researchers at the University of Central Florida have designed an innovative brain-machine interface (BMI) system that can enable throughput of 1,000 or more parallel recordings to repair human cognitive or... Read More

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

Antimicrobial Compositions for Treating Clostridium Infections

33842 – New methods using puupehenone compounds may kill or prevent Clostridium difficile infections. A UCF researcher has developed new methods for using puupehenone compounds to possibly treat illnesses caused by Clostridium bacterial strains, such as C. difficile. Puupehenone is a marine natural product excreted by some species of sponges and coral as a defense mechanism. The UCF invention may... Read More

Novel Compounds to Treat Malaria May Also Alleviate Parasite Drug Resistance

32882 – New Marine-Based Compounds and Aurora Kinase Inhibitors May Effectively Combat Malaria UCF researchers have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs.  The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial... Read More

Block diagram of the experiment used to determine the emission spectra of the samples

Technique for Tagging Therapeutically Relevant Compounds for Tracking and Evaluation Using Infrared Excitation Sources

31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Non-Toxic Motuporamine Analogues to Target Cancer Metastasis

30810 – Novel motuporamine analogues with high anti-metastatic activity and low toxicity. UCF researchers have synthesized novel motuporamine analogues that act as anti-metastatic agents with low toxicity and high anti-migration activities. Motuporamines are naturally occurring anti-cancer compounds isolated from the sea sponge Xestospongia exigua. They have unique anti-migration and... Read More