Healthcare » Drug Delivery, Development and Screening

Found 11 technologies within Drug Delivery, Development and Screening RSS ATOM

Improving Cancer Therapy by Silencing Stemness Genes

34329 – The University of Central Florida invention relates to methods for inhibiting the expression of the “stemness” genes, NANOG/P8 and OCT4 in Glioblastoma Multiforme cancer stem cells. Short hairpin RNAs (shRNAs) were specifically designed to inhibit the expression of NANOG/P8 or OCT4 and were delivered by lentiviral transduction. Exosomal delivery of the shRNAs is currently in... Read More

Polyamine Transport Inhibitors as Antiviral Agents

34459 – Researchers at the University of Central Florida and Boston University are developing polyamine transport inhibitors for use as antiviral compounds. Polyamines are required for a variety of viral processes including replication, protein synthesis, and virus-host interactions. Many viruses, including coronaviruses, have been shown to be sensitive to polyamine depletion. While... Read More

The images compare the flight of respiratory droplets after a simulated sneeze (horizontal velocity versus vertical velocity). Shown are instantaneous velocity contours of saliva, cornstarch and saliva, and mask test cases 185ms after the event starts.

Edible Confections to Reduce Cough- or Sneeze-Induced Pathogen Transmission

34433 – Researchers at the University of Central Florida have developed a composition of edible ingredients that may reduce the transmissibility of airborne pathogens from person to person. Airborne-transmitted pathogens often spread through close contact between humans via respiratory functions. This includes sneezing, coughing, talking and breathing. For example, coughing causes a... Read More

The UCF invention delivers iron to targeted tumor cells to enable ferroptosis-assisted chemodynamic therapy. Image reprinted with permission from Molecular Pharmaceutics 2019, 16, 4852−4866, DOI: 10.1021/acs.molpharmaceut.9b00737. American Chemical Society.

Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy

34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

Low-Cost Test for Distinguishing Between Real and Synthetic Urine

34002 – Test for identifying fake urine when screening workers for illicit drugs UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external... Read More

Block diagram of the experiment used to determine the emission spectra of the samples

Technique for Tagging Therapeutically Relevant Compounds for Tracking and Evaluation Using Infrared Excitation Sources

31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Display of a method of preparing a carbon fiber from a fiber component

An Environmentally Friendly Approach to Cost-Effectively Produce Oxidized Graphite and Prepare Carbon Fiber

32747 – Researchers at the University of Central Florida (UCF) have developed a scalable, environmentally friendly method to produce oxidized graphite. UCF’s oxidized graphite is water dispersible, which aids in the preparation of thin films, carbon fibers, and carbon nanotubes; has resistivities ranging from 50-8,000 Ω/cm2; and, most importantly, allows for easy conversion to graphene. Oxidized... Read More

Non-Toxic Motuporamine Analogues to Target Cancer Metastasis

30810 – Novel motuporamine analogues with high anti-metastatic activity and low toxicity. UCF researchers have synthesized novel motuporamine analogues that act as anti-metastatic agents with low toxicity and high anti-migration activities. Motuporamines are naturally occurring anti-cancer compounds isolated from the sea sponge Xestospongia exigua. They have unique anti-migration and... Read More