Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens
Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab). The identified compounds could potentially be used to treat infections such as tuberculosis (TB), TB-like pulmonary infections, and soft-tissue and wound infections. The compounds may also be effective against drug-resistant strains of mycobacteria.
The research team is looking for partners to further develop the technology for commercialization.
Stage of Development
- Enables the development of noncytotoxic drugs that are active against both Mtb and Mab (and other non-tuberculosis mycobacterial pathogens)
- Can be used to develop novel drugs that target bacterial topoisomerases
Treatment of tuberculosis
Antimicrobial Agents and Chemotherapy. 2018 Apr 26;62(5). pii: e01696-17. doi: 10.1128/AAC.01696-17.