Methods for Using Gold (III) Compounds to Potentially Treat Tuberculosis (TB)

Technology #33894

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Profiles of gold (III) macrocycles that are active against Mtb and Mab.Secondary tuberculosis in lungs and close-up view of Mycobacterium tuberculosis bacteria.
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Researchers
Kyle Rohde, Ph.D.
External Link (med.ucf.edu)
Orde Q. Munro, Ph.D.
External Link (www.wits.ac.za)
Managed By
Brion Berman
Assistant Director 407.882.0342
Patent Protection

PCT Patent Application Filed

Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens

Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab).  The identified compounds could potentially be used to treat infections such as tuberculosis (TB), TB-like pulmonary infections, and soft-tissue and wound infections. The compounds may also be effective against drug-resistant strains of mycobacteria.

Partnering Opportunity

The research team is looking for partners to further develop the technology for commercialization.

Stage of Development

Preclinical

Benefits

  • Enables the development of noncytotoxic drugs that are active against both Mtb and Mab (and other non-tuberculosis mycobacterial pathogens)
  • Can be used to develop novel drugs that target bacterial topoisomerases

Applications

Treatment of tuberculosis