CoCrFeNi-Based Multi-Principal Element Alloys (MPEAs) Ideal for Biomedical Applications

Technology #33866

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Phase contrast micrograph with DiI fluorescent image overlaid, demonstrating the cell morphology surrounding the (a) Co20Cr20Fe20Ni20Mn20 and (b) SS 304 samples after 96 hours of direct contact in the cell culture. The metal samples are black, cells are red.
Stephen Florczyk, Ph.D.
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Brion Berman
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Provisional Patent Application Filed
Direct Contact Cytotoxicity Evaluation of CoCrFeNi-Based High Entropy Alloys poster presentation
Society for Biomaterials 2018 Annual Meeting & Exposition, April 11-14, 2018, Atlanta

New Alloy Materials Enable Stronger, More Ductile and Corrosion-Resistant Orthopedic Implants

UCF researchers have developed CoCrFeNi-based alloy compositions for creating biomedical implant materials with improved corrosion resistance, strength and ductility. The UCF compositions are the first MPEAs tested in vitro to be both non-cytotoxic and able to support fibroblast cell growth in contact with the alloys. This opens the door to designing compositions that more closely mimic bone properties than the biomedical alloys that are currently available.

Technical Details

The UCF invention constitutes compositions of CoCrFeNi-based MPEAs, also known as high entropy alloys (HEAs), for example: Co20Cr20Fe20Ni20Mn20, Co20Cr20Fe30Ni30 and Co30Cr30Fe20Ni20.


  • Enhanced strength and increased corrosion resistance
  • Reduced risk of metallosis, mechanical failure and stress shielding


  • Orthopedic implant components
  • Orthopedic implant coatings
  • Vascular stent implants