New Coating for Prosthetic Implants Helps to Reduce Inflammation and Bone Loss

Technology #33321

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A schematic showing the mechanisms by which a NC coating can prevent osteolysis by scavenging free radicals, suppressing immune reaction locally and inhibiting corrosion, in accordance with an embodiment.
Sudipta Seal, Ph.D.
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Soumen Das, Ph.D.
William Self, Ph.D.
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US Patent Pending

UCF researchers have invented a cerium oxide based coating with anti-inflammatory/anti-oxidant properties that may delay or prevent osteolysis by reducing inflammation and the presence of free radicals while restoring the environment’s electrochemical balance.

The American Academy of Orthopedic Surgeons has projected the number of annual primary total hip joint replacement surgeries to increase over 748,000 in the United States (4 million worldwide) by 2030. Despite technological advances and improvements in treatment strategies to manage rheumatoid arthritis and osteoarthritis, in many cases, total joint replacement (TJR) still remains the final treatment option to relieve pain and to improve quality of life. The annual cost of TJR procedures in the U.S. is more than $10 billion, and the related annual hospital costs estimated to surpass $65 billion by 2015.

Although joint replacement surgeries have made remarkable progress, 10-15 percent of surgeries still fail due to high levels of free radicals, chronic inflammation from joint particles or debris generation through wear, and osteolysis (bone loss), or electrochemical dissolution/corrosion, requiring a growing number of revision surgeries.These type of operations are 40 percent more costly than primary total hip and knee arthroplasties, and more than $1 billion are spent on these procedures each year in the United States alone.


  • Reduces complications of joint replacement surgeries
    • Reduces chronic inflammation
    • Reduces bone loss
    • Enhances bone cell attachment and subsequent osseointegration


  • Coating prosthetic implants