Rapid, Cost-Effective Test for Mycobacteria

Technology #33286

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A rapid, cost-effective method to test samples for mycobacterial infection
Categories
Researchers
Saleh A. Naser, Ph.D.
External Link (med.ucf.edu)
Managed By
Brion Berman
Sr. Licensing Associate 407.882.0342
Patent Protection

US Patent Pending
Publications
Oxidative stress due to Mycobacterium avium subspecies paratuberculosis (MAP) infection upregulates selenium‑dependent GPx activity
Gut Pathogens, March 2016, Volume 8, Issue 12,

UCF researchers have discovered a rapid, cost-effective method to test samples for mycobacterial infection. This measurement can be obtained by assaying a biological sample from the subject, providing a more cost effective, less labor intensive testing process. Once a mycobacterium is identified, this method can be further used to monitor the infection after treatment with an antibiotic.

Background

Bacterial infections are a major global healthcare problem. Mycobacterial infections are believed to be involved in the pathogenesis of many diseases, including inflammatory bowel disease (e.g., Crohn’s disease and ulcerative colitis), tuberculosis, Type 1 diabetes mellitus, and multiple sclerosis. A key challenge in obtaining more rapid diagnoses and providing subsequent treatment is that currently available detection methods of mycobacteria require several months of culture incubation and/or molecular techniques, such as polymerase chain reaction (PCR), requiring extensive time, labor, and costs, as well as delays any potential therapeutic intervention.

Technical Details

Mycobacterial infections can be detected in biological samples (bodily fluids or tissue sample) with standard detection methods such as high-performance liquid chromatography (HPLC), immunoassay, and colorimetric assay. These methods can be used to directly, as well as indirectly, detect the presence of selenium (HPLC) or selenoprotein (immunoassay or colorimetric assay).

Looking for Partners

Looking for a partner to validate testing, conduct pre-clinical and clinical testing, and commercialize the technology.

Stage of Development

Initial laboratory tested; pre-clinical and clinical validation

Benefits

  • Cost-effective
  • Rapid test results
  • Less labor intensive

Applications

  • Pathology labs
  • Agriculture
    • Dairy industries
    • Beef industries