Therapy for the Targeted Treatment of Metastatic Breast Cancer

Technology #32503

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Nanoparticles (A), cells (B) and (C) nanoparticles encapsulating the CT20p peptide deliveryto cells
Categories
Researchers
Annette Khaled, Ph.D.
Manny Perez Figueroa, Ph.D.
Rebecca Boohaker
Michael Lee, Ph.D.
Managed By
Brion Berman
Sr. Licensing Associate 407.882.0342
Patent Protection

METHODS AND COMPOSITIONS COMPRISING A C-TERMINAL BAX PEPTIDE

US Patent 9,040,662 B2
Publications
The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption
Cell Death and Disease, 2014 5:1

This technology is licensed; seeking investment partners.

Nanoparticle-based therapy for the targeted treatment of metastatic breast cancer

Over 1 million new cases of breast cancer are diagnosed globally each year. The majority of breast cancer deaths are due to metastasis, the spreading of the cancer to other sites in the body. There is no cure for metastatic, stage IV, breast cancer and most of the available treatments generally involve chemotherapy which can have toxic side effects due to a lack of specificity.

Invention

UCF researchers have developed a nanoparticle-based technology for targeted treatment of metastatic breast cancer. It features a proprietary therapeutic peptide encapsulated in a cancer targeting nanoparticle that has been optimized for in vivo drug delivery. Treatment with the nanoparticle-peptide complex reduced the motility of metastatic breast cancer cells in vitro and resulted in significant tumor regression in a breast cancer mouse model.

Looking for Partners

We are seeking funding and partners to further develop this technology for clinical use.

Stage of Development

Preclinical

Benefits

  • Targeted treatment
  • Minimal side effects to healthy cells
  • Cost-effective to produce

Applications

  • Cancer therapy


Additional Technology Numbers: 32945, 32946, 32947