Oxidase Activity of Polymeric Coated Cerium Oxide Nanoparticles

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Schematic drawing of nanoceria mediated oxidation of Ampliflu to produce a stable fluorescent product
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Researchers
Manny Perez Figueroa, Ph.D.
Atul Asati
Charalambos Kaittanis
Sudip Nath
Santimukul Santra
Managed By
Andrea Adkins
Assistant Director 407.823.0138
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Oxidase activity of polymeric coated cerium oxide nanoparticles

US Patent 8,883,519 B1

The use of polymer coated nanoceria as an aqueous oxidizing agent with enhanced activities at an acid pH

Technical Details

Redox reactions are utilized in a wide variety of industrial and research applications, establishing a need for a reliable and efficient redox catalyst. Recently, University of Central Florida nanoscientists discovered that under lower pHs (1-4), polymer coated nanoceria exhibit strong Oxidase activity. Reagents currently used as oxidants, such as hydrogen peroxide, are chemically unstable, harmful to biological tissues and damaging to the environment. By utilizing a well-studied polymer coating and novel inexpensive nanoparticle synthesis methods a stable redox catalyst was created which displays Oxidase properties at low pHs.

Benefits

  • ELISA based assays incorporating this technology will not require an additional horseradish peroxidase bound antibody or the addition of hydrogen peroxide
  • Oxidase activity is selective to only lower pH environments (pH 1-4)
  • Polymer coated nanoparticles are far more stable than the currently utilized oxidants
  • Cerium oxide polymer coated nanoparticles are inexpensive to produce and conform to FDA and GMC regulations

Applications

  • The polymer coating each nanoceria core provides functional groups for the addition of targeting agents. The particle can thus be utilized in both Enzyme Linked Immunosorbent Assays (ELISA) as well as other immunoassays commonly used in histology which previously utilized horseradish peroxidase and required hydrogen peroxide. Other redox applications include the decomposition, decontamination or inactivation by oxidation of organic contaminants such as microorganisms or toxins for water treatment.

Additional Technology Numbers: 33121