Polymer Coated Nanoparticles For Selective Cytoprotection

Technology #31194

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(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.
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Researchers
Manuel Perez Figueroa, Ph.D.
Atul Asati
Sudip Nath
Charalambos Kaittanis
Managed By
Andrea Adkins
Assistant Director 407.823.0138
Patent Protection

Polymer coated ceria nanoparticles for selective cytoprotection

US Patent 9,119,391 B1

Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection

Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased cancerous tissue. While these treatments are effective, they are also quite toxic to the rest of the body. The high level of toxicity can often limit the amount of treatment a patient can receive without experiencing extremely negative effects, often leading to under treatment and relapse of the disease.

Technical Details

Polymer coated nanoceria has already been reported to exhibit antioxidant and autocatalytic activities in similar technology produced by University of Central Florida nanoscientists. Additional investigations have noted, however, that the antioxidant properties of these particles are dependant on the pH of the sample. While submerged in a physiological pH the particles exhibited free radical scavenging properties, but when introduced to lower pH levels these properties were reversed showing prominent oxidase activity. It is well established that cancerous tissues (such as tumors) have a far lower pH then the surrounding tissue. This phenomenon presented a method in which an agent could selectively protect healthy non-cancerous tissue from the effects of the treatments, while sensitizing that which is cancerous. Thus by introducing UCF’s coated nanoceria particles to a tumor, one would protect the areas of normal pH (healthy cells) from the effects of the chemotherapeutic treatment, while intensifying the effects in areas of lower pH (cancerous cells).

Benefits

  • Protects only healthy non-cancerous tissue, while sensitizing tumor masses
  • Methods of synthesis are efficient and commercially scalable, conforming with FDA and GMC standards
  • Increases desired effects of current cancer treatments while stifling the undesired side effects

Applications

  • Biomedical applications
  • Cancer treatment
  • Chemotherapeutic treatments


See related technology: “Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications” Technology number: 31005