Polyamines are required in many cellular processes of both eukaryotic and prokaryotic cells. Polyamines contribute to regulation of cell proliferation, cell differentiation, and homeostasis, and have been shown to play specific roles in replication, transcription, and translation. Studies have shown that cancer cells up-regulate polyamine transporters thereby taking in drastically more polyamines. This up-regulation is believed to be the mechanism by which motuporamines help to differentiate cancer cells from healthy cells.
Researchers at UCF have synthesized a wide variety of polyamines which may act as motuporamine mimic agents, drug delivery agents, or fluorescent detection devices for cancer. Due to the discovery of cancer cells up-regulated intake of polyamines enabling their rapid growth and division, the system which uptakes these molecules can be taken advantage of for several purposes. By inhibiting the process, cancer cells lose their ability to grow and divide thereby preventing the cancer from metastasizing. Using a fluorescent dye attached to a polyamine a researcher could easily determine the exact size and location of a tumor. Lastly, if a chemotherapeutic drug were attached to the polyamine, the therapy would gain specificity which would reduce negative effects. Interfering and adapting the polyamine system is a novel and unique approach to cancer which has a very promising future.
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- Specificity for cancer cells
- Simply synthesized
- Detection and treatment of cancer
- Drug delivery
Additional Technology Numbers: 31100, 31105, 31796, 32699, 32716