Polyamines Used for a Variety of Functions

Technology #30810

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Structures ofmotuporamine mimic agents.
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Researchers
Otto Phanstiel, Ph.D.
Kenneth Teter, Ph.D.
Navneet Kaur
Managed By
Brion Berman
Sr. Licensing Associate 407.882.0342
Patent Protection

Lipophilic polyamines providing enhanced intracellular delivery of agents by a polyamine transport system

US Patent 7,910,363 B1

Fluorescent cytotoxic compounds specific for the cellular polyamine transport system US 8410311 B1

US Patent 8,410,311 B1

Polyamine transporter selective compounds as anti-cancer agents

US Patent 8,497,398 B1

Fluorescent cytotoxic compounds specific for the cellular polyamine transport system

US Patent 9,285,320

Polyamine transporter selective compounds as anti cancer agents

US Patent 9,150,495

Motuporamine mimic agents

US Patent 7,728,041 B2
Publications
Journal of Medicinal Chemistry , 2014, 57 (10), 4023-4034
Journal of Medicinal Chemistry , 2014, 56 (14), pp 5819-5828

Polyamines are required in many cellular processes of both eukaryotic and prokaryotic cells. Polyamines contribute to regulation of cell proliferation, cell differentiation, and homeostasis, and have been shown to play specific roles in replication, transcription, and translation. Studies have shown that cancer cells up-regulate polyamine transporters thereby taking in drastically more polyamines. This up-regulation is believed to be the mechanism by which motuporamines help to differentiate cancer cells from healthy cells.

Technical Details

Researchers at UCF have synthesized a wide variety of polyamines which may act as motuporamine mimic agents, drug delivery agents, or fluorescent detection devices for cancer. Due to the discovery of cancer cells up-regulated intake of polyamines enabling their rapid growth and division, the system which uptakes these molecules can be taken advantage of for several purposes. By inhibiting the process, cancer cells lose their ability to grow and divide thereby preventing the cancer from metastasizing. Using a fluorescent dye attached to a polyamine a researcher could easily determine the exact size and location of a tumor. Lastly, if a chemotherapeutic drug were attached to the polyamine, the therapy would gain specificity which would reduce negative effects. Interfering and adapting the polyamine system is a novel and unique approach to cancer which has a very promising future.

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Benefits

  • Specificity for cancer cells
  • Simply synthesized
  • Multi-functional

Applications

  • Detection and treatment of cancer
  • Drug delivery


Additional Technology Numbers: 31100, 31105, 31796, 32699, 32716