Healthcare » Oncology

Found 8 technologies within Oncology RSS ATOM

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Perspective view of a first preferred embodiment of the novel probe and receiver device for simultaneous acquisition of spatial and spectral OCT (SI-OCT)

Simultaneous Spatial Imaging and Spectral Sensing for the Diagnosis of Cervical and Skin Cancers

30450 – A probe that simultaneously performs optical coherence tomography (OCT) and spectral analysis using back reflected light The present invention provides a tunable source of low-coherence light to simultaneously conduct spatial imaging and spectral sensing for tissue diagnosis. It offers a real time three dimensional colposcopy diagnosis and the detailed guidance to physically biopsy... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Schematic representation of polymer-coated nanoceria with different surface charges displaying cell internalization, discrete subcellular localization and toxicity profiles

Target Cancer Cells with Coated Nanoceria

33361 – UCF researchers have created a new weapon in the fight against cancer by coating nanoparticles of cerium oxide, nanoceria, with polymers to affect the localization of nanoceria within cells and modulate its toxicity based on pH, to fight cancer cells while protecting normal cells. Even in the presence of oxygen, many cancers preferentially obtain their energy by converting glucose into... Read More

Polyamines Used for a Variety of Functions

30810 – Polyamines are required in many cellular processes of both eukaryotic and prokaryotic cells. Polyamines contribute to regulation of cell proliferation, cell differentiation, and homeostasis, and have been shown to play specific roles in replication, transcription, and translation. Studies have shown that cancer cells up-regulate polyamine transporters thereby taking in drastically more... Read More

Nanoparticles (A), cells (B) and (C) nanoparticles encapsulating the CT20p peptide deliveryto cells

Therapy for the Targeted Treatment of Metastatic Breast Cancer

32503 – This technology is licensed; seeking investment partners. Nanoparticle-based therapy for the targeted treatment of metastatic breast cancer Over 1 million new cases of breast cancer are diagnosed globally each year. The majority of breast cancer deaths are due to metastasis, the spreading of the cancer to other sites in the body. There is no cure for metastatic, stage IV, breast cancer... Read More