Healthcare » Oncology

Found 13 technologies within Oncology RSS ATOM

Polyamine Transport Inhibitors to Activate an Anti-Tumor Immune Response

11057 – Researchers at the University of Central Florida and the Lankenau Institute for Medical Research have synthesized new anti-cancer small molecules that block polyamine uptake and activate the anti-tumor immune response. Many tumors require high levels of polyamines to support their growth and survival. Additionally, high levels of polyamines can suppress the immune system, allowing... Read More

Two-Stage Method for Reliable Routine Cancer Screening

34509 – The University of Central Florida invention relates to a two-step, blood-based cancer screening test. The first step screens for elevated levels of Fibroblast Growth Factor 19 (FGF19) via a standard enzyme-linked immunosorbent assay (ELISA). Patients with elevated levels of FGF19 continue with a second/follow-up test using oral cholestyramine as a “suppression” drug to verify that... Read More

Targeting Cancer Stem Cells with RNAi

34329 – Researchers at the University of Central Florida are developing RNA interference (RNAi)-based therapies for increasing the sensitivity of cancer stem cells to chemotherapy. Cancer stem cells are a specialized subset of tumor cells that are often resistant to cancer therapy. This technology targets the expression of the embryonic stem cell genes NANOG or OCT4 which are expressed in... Read More

The UCF invention delivers iron to targeted tumor cells to enable ferroptosis-assisted chemodynamic therapy. Image reprinted with permission from Molecular Pharmaceutics 2019, 16, 4852−4866, DOI: 10.1021/acs.molpharmaceut.9b00737. American Chemical Society.

Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy

34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Perspective view of a first preferred embodiment of the novel probe and receiver device for simultaneous acquisition of spatial and spectral OCT (SI-OCT)

Simultaneous Spatial Imaging and Spectral Sensing for the Diagnosis of Cervical and Skin Cancers

30450 – A probe that simultaneously performs optical coherence tomography (OCT) and spectral analysis using back reflected light The present invention provides a tunable source of low-coherence light to simultaneously conduct spatial imaging and spectral sensing for tissue diagnosis. It offers a real time three dimensional colposcopy diagnosis and the detailed guidance to physically biopsy... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Schematic representation of polymer-coated nanoceria with different surface charges displaying cell internalization, discrete subcellular localization and toxicity profiles

Target Cancer Cells with Coated Nanoceria

33361 – UCF researchers have created a new weapon in the fight against cancer by coating nanoparticles of cerium oxide, nanoceria, with polymers to affect the localization of nanoceria within cells and modulate its toxicity based on pH, to fight cancer cells while protecting normal cells. Even in the presence of oxygen, many cancers preferentially obtain their energy by converting glucose into... Read More

Non-Toxic Motuporamine Analogues to Target Cancer Metastasis

30810 – Novel motuporamine analogues with high anti-metastatic activity and low toxicity. UCF researchers have synthesized novel motuporamine analogues that act as anti-metastatic agents with low toxicity and high anti-migration activities. Motuporamines are naturally occurring anti-cancer compounds isolated from the sea sponge Xestospongia exigua. They have unique anti-migration and... Read More