Healthcare » Diagnostics

Found 36 technologies within Diagnostics RSS ATOM
Dark field optical microscope image of CMV inclusion bodies observed from a positive urine sample.

Method and Device for Pathogen or Antibody Detection Using Unmodified Signaling Substances With or Without Unlabeled Detection Reagents

11472 – The University of Central Florida invention relates to methods for detecting a target pathogen or antibody in biological samples. The disclosed methods include three embodiments and do not require labeling or conjugating of the detection reagent with the signaling molecule or substance to generate detectable signals. The first embodiment relates to using an unlabeled antibody... Read More

Complex Refractive-Index Imaging by Iterative Optical Diffraction Tomography

11459 – Researchers at the University of Central Florida have invented a technique for capturing and reconstructing images of phase objects with greater accuracy and quality than conventional optical diffraction tomography (ODT) inversion methods. Example objects include transparent samples such as biological cells, tissues and optical fibers with high contrast, complicated structure, or... Read More

Procedure for Determining DNA barcodes for Efficient Species Categorization Using Nanopore Translocation

34583 – The University of Central Florida invention relates to methods for measuring DNA barcodes using single or multi‐nanopore platforms. Barcodes are calculated by observing the detail motion of the dsDNA segments in between the barcodes using Brownian dynamics simulation.

Two-Stage Method for Reliable Routine Cancer Screening

34509 – The University of Central Florida invention relates to a two-step, blood-based cancer screening test. The first step screens for elevated levels of Fibroblast Growth Factor 19 (FGF19) via a standard enzyme-linked immunosorbent assay (ELISA). Patients with elevated levels of FGF19 continue with a second/follow-up test using oral cholestyramine as a “suppression” drug to verify that... Read More

Optical images of the Hypo-Rig after printing and assembly: (A) shows the assembled rig and release stamp. (B) demonstrates the assembly working together for release. (C) demonstrates the assembly in practice, for alignment with a custom culture well no larger than 16mm in diameter. The device is scalable for larger devices, and the density of dispensing needles can also increase.

Makerspace Fabrication Technology for Faster, Precise Production of 3D Metal Microelectrode Arrays (MEAs)

34429 – Researchers at the University of Central Florida have developed a simple, inexpensive solution for fabricating 3D metal microelectrode arrays (MEAs) and microneedle platforms. Compared to current technologies, the UCF makerspace technology overcomes issues such as brittleness, high expense, complexity, and unrepeatable processes. As a result, the invention offers cost-... Read More

Highly Porous Frozen Films Enable Easier Cell Seeding, Cell Recovery and Imaging as Biomaterial Substrates

34371 – University of Central Florida researchers have developed biomaterial substrates that combine the benefits of 2D and 3D culture platforms while limiting the drawbacks. The UCF frozen films (FFs) are highly porous thin films with micron-scale porosity and fibrous struts. As biomaterial substrates, the FFs better replicate in vivo conditions and enable cells to attach quicker than 2D... Read More

Exosomal NANOG DNA as a Diagnostic Cancer Marker

34174 – The University of Central Florida invention relates to the use of NANOG exosomal DNA as a diagnostic cancer marker.  Specifically, the marker is a 22bp insert in the 3’UTR of the NANOG pseudogene, NANOGP8. Exosomes are extracellular microvesicles (30-100 nm) released by almost all types of cells upon fusion of the multi-vesicular body with the plasma membrane. Known for their role in... Read More

Novel Carbapenems to Combat Drug-Resistant Mycobacteria

33910 – Researchers at the University of Central Florida and Southern Methodist University have developed novel carbapenem antibiotics that exhibit enhanced activity against drug-resistant strains of mycobacterial species, such as Mycobacterium tuberculosis (Mtb) and Micobacterium abscessus (Mabs). The narrow-spectrum carbapenems selectively target mycobacterial L, D-transpeptidases. In... Read More

CRISPR-Based Imaging System Detects Target Gene Loci in Live Cells

34082 – Researchers at the University of Central Florida and the University of Massachusetts have developed a CRISPR-based system for detecting DNA repeat expansion sequences—genetic mutations that cause diseases such as amyotrophic lateral sclerosis (ALS). The CRISPR Arrayed Repeat Detection System (CARDS) can detect multiple mutated genes simultaneously in a single assay.... Read More

Capsule-Based System for Object Segmentation Offers Accuracy at Less Cost

34138 – New SegCaps deep learning architecture enables more cost-effective segmentation of medical images. Researchers at the University of Central Florida have developed an innovative capsule-based deep learning system that requires far less parameterization to perform object segmentation more accurately and efficiently than state-of-the-art convolutional neural networks (CNNs) such as U-Net. The... Read More

The diagram provides an overview of the new system for automatically diagnosing IPMNs.

Novel System for Automatically Diagnosing Pancreatic Intraductal Papillary Mucinous Neoplasms

34177 – New diagnostic tool speeds the process of detecting and analyzing precancerous pancreatic cysts. Researchers at the University of Central Florida and the Mayo Clinic have developed an automated system that enables radiologists to detect and assess the cancer risk of pancreatic cysts faster and more effectively than using conventional MRI technology and radiographic guidelines. The cysts,... Read More

Figure 1. An example of a packaged device made using the invention (left) and its 4D characteristics (right).

4D Biosensors for Lab-On-A-Chip and Wearable Sensor Applications

34078 – Innovative 4D biosensor technology with shape-memory recovery enables integration with implantable systems for electrical measurements. Researchers at the University of Central Florida have developed a novel 4D biosensor for lab-on-a-chip and wearable sensor applications that is more cost-effective and easier to manufacture than current technologies. Made of dynamic, stretchable, packaged... Read More

Example diagrams of the UCF tactile display apparatus design: (a) shows an external view and (b) shows an internal view of the device.

Tactile Display Apparatus for Palpation Simulation and Telemedicine

34063 – Innovative training device enables medical students to experience the near-real sensation of touch, similar to human palpation. Researchers at the University of Central Florida have designed a haptic training device that medical students can use to better distinguish between normal and abnormal lumps in the body. By providing the sensation of touch and the ability to vary the size and... Read More

As shown in figures (a) and (b), the new UCF blood-sampling syringe fully incorporates a nucleic acid purification function. The graph (c) shows the effectiveness of the tool’s DNA capture. Researchers used a real-time PCR to quantify and compare the captured DNA to the original blood sample.

Novel Syringe for One-Step RNA/DNA Purification and Medical Diagnosis

34133 – Integrated syringe combines blood sample collection and nucleic acid preparation functions to speed diagnostic testing for infectious diseases. Researchers at the University of Central Florida have designed an innovative syringe that can simultaneously draw a patient’s blood and extract/purify nucleic acids from the sample. Thus, a simple blood draw results in a prepared sample ready for... Read More

Figure 1. The graphic (a) schematically illustrates an experimental incoherent light-illuminated DCNN-GALOF imaging system without distal optics. The light source is a low-cost LED. To quantify the amount of fiber bending (b) the offset distance was measured as the distance from the end of the bent fiber to the position of the straight fiber (equal to the length of the dashed line).

Glass-Air Optical Fiber Imaging for Accurate, Real-Time Views of Biological Objects

34029 – New approach can transmit artifact-free images of cell structures in vivo despite temperature fluctuations and optical fiber bending. Researchers at the University of Central Florida have developed a lensless fiber-optic imaging system that overcomes the expense and complications associated with existing multicore and multimode fiber-based imaging systems (MCFs, MMFs). More robust, compact... Read More

Lyme Disease Diagnostic Test Combines the Sensitivity of PCR with the Specificity of Immunoassays

33429 – Immuno-PCR Based Approach Enables Early and Objective Diagnosis of Lyme Disease Researchers at the University of Central Florida (UCF) have developed a multiplex immuno-PCR (iPCR) based diagnostic test which improves upon currently available approaches for Lyme disease detection. Lyme disease is caused by the bacteria Borrelia burgdorferi (B. burgdorferi) and is transmitted to humans and... Read More

An example diagram of the noninvasive, portable, aspiration detection system.

Portable Breath Gas Analysis System

34004 – Low-cost, noninvasive, point-of-care system quickly detects aspiration in dysphasia patients. Researchers at the University of Central Florida have invented a fast and simple way to quickly detect pulmonary aspiration in patients with dysphasia (difficulty swallowing) or other conditions that put them at risk for aspiration-related illnesses. Pulmonary aspiration occurs when people inhale... Read More

Figure 1. An isometric, conceptual view of a toy bear with integrated data sensors.

Novel System for Capturing, Quantifying and Analyzing Therapy Interactions

33898 – Innovation aids counselors in diagnosing and treating a child’s behavioral disorder using quantifiable evidence from play therapy sessions. UCF researchers have designed a system that mental health professionals can use to capture and track quantifiable data about a child’s development and behavior during therapy sessions. The Science of Play system works in real time, monitoring... Read More

Figure (a) shows a schematic representation of chiral light-matter interaction between left-circularly polarized (LCP) and (s) enantiomer; (b) shows a top view of one uncoated sample and cross-section view of one polymer-coated substrate embedding the chiral molecule; (c) shows a representation for the optical characterization.

Molecular Chirality Detection Technique using Hybrid Plasmonic Substrates

33902 – System offers low-cost methods for efficiently and accurately detecting low levels of left- and right-handed enantiomers of drugs seeking FDA approval University of Central Florida researchers have designed a system that can accurately identify the chirality of drugs, proteins, DNA and other molecules at lower detection limits than conventional detection systems. With the ability to... Read More

Low-Cost Test for Distinguishing Between Real and Synthetic Urine

34002 – Test for identifying fake urine when screening workers for illicit drugs UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external... Read More

Profiles of gold (III) macrocycles that are active against Mtb and Mab.

Methods for Using Gold (III) Compounds to Potentially Treat Tuberculosis (TB)

33894 – Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab).  The identified compounds... Read More

Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays (MEAs) with Spin-Coated Insulation and Functional Electrospun 3D Scaffolds

33871 – New MEA fabrication technology enables the development of rapid assays with 3D cell-based biosensors for toxicity testing, disease modeling and optical/electrical stimulation of cell types. Exploded view of the 3D MEA: 3D microtowers, metallization, laminate insulation and containment culture well with a close-up of 10 recording sites per patch. Fully functional for “disease in a... Read More

Diagram (a) illustrates the new UCF 3D-printing technique used to produce 3D-printed porous scaffolds for cell culture. Image (b) shows the honeycomb design of scaffolds and the actual appearance of scaffolds with different processing routes after recovery from a gelatin bath. Recovered prints were immersed in cell culture media to reveal pore formation with the existence of bubbles inside the struts. Scale bars are 10mm.

3D-Printing Technique for Creating Biomaterial Structures with Tailored Hierarchical Porosity

33859 – Novel printing technique enables the production of custom porous 3D printed biomaterial scaffolds. UCF researchers have developed a new 3D printing technique to produce biomaterial scaffolds with controlled porosity. This technique enables the design and production of 3D printed structures with pores throughout the scaffold, providing additional sites for seeded cells to adhere and grow. ... Read More

Prostate cancer C4-2B cells on different stiffness CA scaffolds. Mineralization increases with stiffness.

3D Biomaterial Scaffolds Mimic Tumor Microenvironment and Enable Drug Screening for Personalized Cancer Therapies

33849 – New 3D biomaterial scaffold enables testing of chemotherapies before administering to patients Researchers at UCF and the Mayo Clinic are developing a diagnostic tool for predicting patient outcome in response to a particular cancer treatment. The tool consists of biomaterial scaffolds that mimic the in vivo 3D structure of the tumor microenvironment and can be used as an in vitro platform... Read More

UCF’s Young Adult and Adolescent Male Health Behavior Indicators Scale enables health organizations to gain deeper insight into the health-related attitudes, perceptions and experiences of YAAM populations and the health disparities that they encounter.

Assessment Tool Identifies Male Behavior and Attitudes Toward Healthcare

33783 – Survey Tool Enables Researchers to Capture Critical Data about Promoting Health Services to Young Adult Males UCF researchers have developed a valuable survey tool that can help organizations improve their healthcare service and delivery systems aimed at young adult and adolescent males (YAAMs). With the Young Adult and Adolescent Male Health Behavior Indicators Scale, health... Read More

Decision Support System Helps Hospitals Prevent Heart Failure Readmissions

33648 – Low-cost, innovative support tool enables care managers to implement interventions that prevent readmissions and improve the health outcomes of patients with heart failure UCF researchers have invented a decision support tool for enhancing patient care and reducing hospital readmissions related to heart failure (HF). The innovative support tool identifies and analyzes patient-centric human... Read More

Figure 1. Left image: Dotted red lines show the abdominal region boundaries on the left. Right image: A thin discontinuous muscle wall (dotted blue curve) separates VAT and SAT.

First Automated System to Quantify White and Brown Adipose Tissue at the Whole-Body, Body-Region and Organ Levels

33690 – Innovative system enables clinicians to better assess health risks of obese patients by accurately identifying and quantifying body fats UCF researchers have developed the first automated system to provide accurate, quantitative data regarding a person’s white and brown body fat (adipose tissue) levels. The innovation enables clinicians to better assess possible health issues and risks... Read More

Blood clotting

Breakthrough Optical Blood Coagulation Monitor Provides Real-time Feedback

31064 – Life-saving device continuously checks a patient’s blood clotting status during and after surgery UCF researchers have developed a breakthrough early-detection system that helps detect life-threatening blood clots during and after a medical procedure. Conventional laboratory blood coagulation tests are time-intensive, requiring blood to be drawn, processed and analyzed. The UCF real-time... Read More

Schematic representation of the fabrication and use of the ISE.

Ready-to-Use Paper Ion Sensor for On-Site Analysis

33425 – Ion-selective electrodes (ISEs) are highly important for ion detection. Paper-based ISEs are a simple, low cost, and disposable alternative to conventional solid-contact ISEs. However, widespread use of paper-based ISEs has been limited due to poor detection limits (in the micromolar range), reliability, and selectivity.  UCF researchers have developed novel ultra-sensitive paper-based ISEs... Read More

Dementia and delirium tool

The Dementia and Delirium Analysis Research Tool

33410 – An easy-to-use, accessible questionnaire that both clinicians and caregivers can use with dementia and delirium patients Currently, screenings for delirium and dementia are performed separately and administered by a trained professional. However, this process is inconvenient and time consuming for both the clinician and the patient, often leading to misdiagnoses in busy clinical settings... Read More

Perspective view of a first preferred embodiment of the novel probe and receiver device for simultaneous acquisition of spatial and spectral OCT (SI-OCT)

Simultaneous Spatial Imaging and Spectral Sensing for the Diagnosis of Cervical and Skin Cancers

30450 – A probe that simultaneously performs optical coherence tomography (OCT) and spectral analysis using back reflected light The present invention provides a tunable source of low-coherence light to simultaneously conduct spatial imaging and spectral sensing for tissue diagnosis. It offers a real time three dimensional colposcopy diagnosis and the detailed guidance to physically biopsy... Read More

Scheme showing microarrays of enzyme assisted probes

Fluorescent Detection of Nucleic Acid Sequences using Binary Probes System

32131 – This invention is a new enzyme-assisted detection system for analyzing nucleic acids with real-time fluorescent signal generation Detection of nucleic acid sequences is critical for disease diagnosis, drug development, biomedical research, and forensic testing. A nucleic acid reporter is commonly used for the detection of specific sequences. This reporter probe is labeled with a... Read More

Cerium oxide coated electrode with electronic circuit

Faster Detection of Free Radicals

30949 – A nanoceria based regenerative radical sensor for plasma testing, food quality control, or drug development UCF researchers have developed an electrochemical sensor for the measurement of free radicals, or materials that generate free radicals, in solution. Ideal for biomedical, pharmaceutical, or sensor companies, this sensor has a long lifetime with the option of multiple uses. With an... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Schematics of the spatially resolved confocal absorption microscopy setup

Improve Micro-scale and Single-cell Optical Diagnostics

32371 – UCF researchers have developed absorption spectroscopy technology to measure samples at the micron and single cell level. Conventional optical probe technology required samples larger than micron size, limiting usability in fields with finite samples, including forensic analysis. This new technology is non-destructive to the sample, for continued testing and maximized data results.... Read More