Healthcare

1-50 of 73 technologies within Healthcare RSS ATOM

Improving Cancer Therapy by Silencing Stemness Genes

34329 – The University of Central Florida invention relates to methods for inhibiting the expression of the “stemness” genes, NANOG/P8 and OCT4 in Glioblastoma Multiforme cancer stem cells. Short hairpin RNAs (shRNAs) were specifically designed to inhibit the expression of NANOG/P8 or OCT4 and were delivered by lentiviral transduction. Exosomal delivery of the shRNAs is currently in... Read More

Optical images of the Hypo-Rig after printing and assembly: (A) shows the assembled rig and release stamp. (B) demonstrates the assembly working together for release. (C) demonstrates the assembly in practice, for alignment with a custom culture well no larger than 16mm in diameter. The device is scalable for larger devices, and the density of dispensing needles can also increase.

Makerspace Fabrication Technology for Faster, Precise Production of 3D Metal Microelectrode Arrays (MEAs)

34429 – Researchers at the University of Central Florida have developed a simple, inexpensive solution for fabricating 3D metal microelectrode arrays (MEAs) and microneedle platforms. Compared to current technologies, the UCF makerspace technology overcomes issues such as brittleness, high expense, complexity, and unrepeatable processes. As a result, the invention offers cost-... Read More

Frozen Films, Highly Porous Thin Films

34371 – The University of Central Florida invention relates to the development of biomaterial substrates known as frozen films. The frozen films are highly porous thin films with micron-scale porosity and fibrous struts. The frozen films are expected to be compatible with high-throughput screening systems used by pharmaceutical companies and biotech companies for pre-clinical drug... Read More

3D Microelectrode Array for Optical and Electrical Probing of Electrogenic Cells

34513 – The University of Central Florida invention describes the microfabrication and assembly of a three-dimensional microelectrode array (3D MEA) based on a glass-stainless steel platform. The technique involves the use of non-traditional “Makerspace Microfabrication” techniques, which allows cost effective fabrication of the device using biocompatible materials.

Exosomal NANOG DNA as a Diagnostic Cancer Marker

34174 – The University of Central Florida invention relates to the use of NANOG exosomal DNA as a diagnostic cancer marker. Specifically, the marker is a 22bp insert in the 3’UTR of the NANOG pseudogene, NANOGP8. Exosomes are extracellular microvesicles (30-100 nm) released by almost all types of cells upon fusion of the multi-vesicular body with the plasma membrane. Known for their role in... Read More

Method to Evaluate Chronic Condition Diagnoses in Electronic Medical Records

34565 – The University of Central Florida invention describes a scoring algorithm called Chronic Condition Mapping Package (CCMP). The invention can track chronic condition diagnoses in terms of completeness, consistency, and accuracy relative to established guidelines. There is a need to track chronic condition diagnoses and appropriately determine the staging and management of conditions.... Read More

Direct Reprogramming of Mesenchymal Stems Cells to Neural Stem Cell-Like Cells

34445 – Researchers at the University of Central Florida have developed a xeno-free and transgene-free method for reprogramming mesenchymal stem cells to neural stem cell-like cells. Neural stem cells are difficult to obtain for therapeutic use due to their location in the brain. As an alternative, multipotent mesenchymal stem cells are a potential source of neural stem cells, but must... Read More

Polyamine Transport Inhibitors as Antiviral Agents

34459 – Researchers at the University of Central Florida and Boston University are developing polyamine transport inhibitors for use as antiviral compounds. Polyamines are required for a variety of viral processes including replication, protein synthesis, and virus-host interactions. Many viruses, including coronaviruses, have been shown to be sensitive to polyamine depletion. While... Read More

Fungus-Derived Compounds to Fight Drug-Resistant Malaria

34250 – Researchers at the University of Central Florida and the University of Oklahoma have identified fungus-derived compounds for developing treatments against drug-resistant species of Plasmodium. Compounds collected from a large library of diverse fungi (including pure compounds and extracts) may enable scientists to target new cellular structures of malaria-causing parasites such as... Read More

Novel Carbapenems to Combat Drug-Resistant Mycobacteria

33910 – Researchers at the University of Central Florida and Southern Methodist University have developed novel carbapenem antibiotics that exhibit enhanced activity against drug-resistant strains of mycobacterial species, such as Mycobacterium tuberculosis (Mtb) and Micobacterium abscessus (Mabs). The narrow-spectrum carbapenems selectively target mycobacterial L, D-transpeptidases. In... Read More

Energy-Efficient, Real-Time Variable Stiffness Ankle-Foot Prosthesis

34461 – Researchers at the University of Central Florida have developed an innovative, bio-inspired ankle-foot prosthesis that can automatically adjust its ankle stiffness to accommodate different activities. For example, the device can quickly adapt to walking conditions such as inclines, declines, and uneven soft or hard surfaces. The novel prosthesis uses a highly efficient energy... Read More

Convenient, Self-Sterilizing Rollable Face Mask for Everyday Use

34460 – Researchers at the University of Central Florida have designed a face mask that conveniently rolls into a necklace-like device that also sterilizes the mask when not in use. The World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) strongly recommend wearing a mask to prevent infections and to mitigate the spread of contagious diseases... Read More

CRISPR-Based Imaging System Detects Target Gene Loci in Live Cells

34082 – Researchers at the University of Central Florida and the University of Massachusetts have developed a CRISPR-based system for detecting DNA repeat expansion sequences—genetic mutations that cause diseases such as amyotrophic lateral sclerosis (ALS). The CRISPR Arrayed Repeat Detection System (CARDS) can detect multiple mutated genes simultaneously in a single assay.... Read More

The images compare the flight of respiratory droplets after a simulated sneeze (horizontal velocity versus vertical velocity). Shown are instantaneous velocity contours of saliva, cornstarch and saliva, and mask test cases 185ms after the event starts.

Edible Confections to Reduce Cough- or Sneeze-Induced Pathogen Transmission

34433 – Researchers at the University of Central Florida have developed a composition of edible ingredients that may reduce the transmissibility of airborne pathogens from person to person. Airborne-transmitted pathogens often spread through close contact between humans via respiratory functions. This includes sneezing, coughing, talking and breathing. For example, coughing causes a... Read More

Example prototype of the UCF 3D-printed fingertip pediatric laryngoscope-intubation device.

3D-Printed Fingertip Pediatric Laryngoscope for Safer, Faster Intubation

34054 – New flexible device can be custom-printed to fit a child’s respiratory tract and minimize intubation trauma from surgical procedures. Researchers at the University of Central Florida have developed a combined pediatric laryngoscope and intubation medical device that facilitates tracheal intubation while reducing patient trauma. The low-cost, 3D-printed innovation is more flexible and... Read More

Schematic illustration of the UCF nano-coating.

Nano-Coating Captures and Kills Viruses on Personal Protective Equipment (PPE)

34370 – Polymer-based, antiviral coating may kill pathogens on face masks and gloves to prevent surface-to-surface contamination Researchers at the University of Central Florida have developed an innovative nano-coating designed to capture and kill viruses on PPEs and other medical equipment. For example, the invention may be used to target SARS-CoV-2, the virus that causes the COVID-19 disease.... Read More

COVID-19 Training Cards Offer Easy Access to Key Safety Information

34378 – New training cards provide CDC-recommended steps for fighting the spread of COVID-19 Researchers at the University of Central Florida have developed educational training cards about COVID-19 and ways to stay safe from the disease. The deck of 52 cards provides key information including how the disease spreads and CDC-recommended instructions for preventing and transmitting the disease... Read More

Capsule-Based System for Object Segmentation Offers Accuracy at Less Cost

34138 – New SegCaps deep learning architecture enables more cost-effective segmentation of medical images. Researchers at the University of Central Florida have developed an innovative capsule-based deep learning system that requires far less parameterization to perform object segmentation more accurately and efficiently than state-of-the-art convolutional neural networks (CNNs) such as U-Net. The... Read More

The UCF invention delivers iron to targeted tumor cells to enable ferroptosis-assisted chemodynamic therapy. Image reprinted with permission from Molecular Pharmaceutics 2019, 16, 4852−4866, DOI: 10.1021/acs.molpharmaceut.9b00737. American Chemical Society.

Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy

34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More

The diagram provides an overview of the new system for automatically diagnosing IPMNs.

Novel System for Automatically Diagnosing Pancreatic Intraductal Papillary Mucinous Neoplasms

34177 – New diagnostic tool speeds the process of detecting and analyzing precancerous pancreatic cysts. Researchers at the University of Central Florida and the Mayo Clinic have developed an automated system that enables radiologists to detect and assess the cancer risk of pancreatic cysts faster and more effectively than using conventional MRI technology and radiographic guidelines. The cysts,... Read More

Example of the new prosthetic timing module (in the blue box) attached to a passive prosthesis.

Novel Ankle Prosthetic Module Maximizes the Propulsion Efficiency of Passive Prostheses

34171 – Real-time module enables passive ankle prosthesis to control and release stored energy for optimal propulsion. Researchers at the University of Central Florida have developed a device with a unique learning algorithm to maximize the propulsion efficiency of passive prostheses used by individuals with transtibial (below-knee) amputations. The UCF real-time adjustable energy-releasing device... Read More

Figure 1. An example of a packaged device made using the invention (left) and its 4D characteristics (right).

4D Biosensors for Lab-On-A-Chip and Wearable Sensor Applications

34078 – Innovative 4D biosensor technology with shape-memory recovery enables integration with implantable systems for electrical measurements. Researchers at the University of Central Florida have developed a novel 4D biosensor for lab-on-a-chip and wearable sensor applications that is more cost-effective and easier to manufacture than current technologies. Made of dynamic, stretchable, packaged... Read More

Example diagrams of the UCF tactile display apparatus design: (a) shows an external view and (b) shows an internal view of the device.

Tactile Display Apparatus for Palpation Simulation and Telemedicine

34063 – Innovative training device enables medical students to experience the near-real sensation of touch, similar to human palpation. Researchers at the University of Central Florida have designed a haptic training device that medical students can use to better distinguish between normal and abnormal lumps in the body. By providing the sensation of touch and the ability to vary the size and... Read More

Schematic overview of the UCF approach to predict the biodistribution of nanomaterials in the body.

New Approach for Determining Nanomaterial (NM) Biodistribution in the Body Offers an Alternative to Animal Testing

34037 – System with predictive computer modeling enables nanomaterial drug screening tests that effectively measure NM-cell interactions in vivo. Researchers at the University of Central Florida have developed a new system to quantify and accurately predict the biodistribution of nanomaterials (NMs) in the body, reducing the need for animal studies. Using a novel quantitative fluorescence-based in... Read More

As shown in figures (a) and (b), the new UCF blood-sampling syringe fully incorporates a nucleic acid purification function. The graph (c) shows the effectiveness of the tool’s DNA capture. Researchers used a real-time PCR to quantify and compare the captured DNA to the original blood sample.

Novel Syringe for One-Step Purification and Medical Diagnosis

34133 – Integrated syringe combines blood sample collection and nucleic acid preparation functions to speed diagnostic testing for infectious diseases. Researchers at the University of Central Florida have designed an innovative syringe that can simultaneously draw a patient’s blood and extract/purify nucleic acids from the sample. Thus, a simple blood draw results in a prepared sample ready for... Read More

Figure 1. The graphic (a) schematically illustrates an experimental incoherent light-illuminated DCNN-GALOF imaging system without distal optics. The light source is a low-cost LED. To quantify the amount of fiber bending (b) the offset distance was measured as the distance from the end of the bent fiber to the position of the straight fiber (equal to the length of the dashed line).

Glass-Air Optical Fiber Imaging for Accurate, Real-Time Views of Biological Objects

34029 – New approach can transmit artifact-free images of cell structures in vivo despite temperature fluctuations and optical fiber bending. Researchers at the University of Central Florida have developed a lensless fiber-optic imaging system that overcomes the expense and complications associated with existing multicore and multimode fiber-based imaging systems (MCFs, MMFs). More robust, compact... Read More

Lyme Disease Diagnostic Test Combines the Sensitivity of PCR with the Specificity of Immunoassays

33429 – Immuno-PCR Based Approach Enables Early and Objective Diagnosis of Lyme Disease Researchers at the University of Central Florida (UCF) have developed a multiplex immuno-PCR (iPCR) based diagnostic test which improves upon currently available approaches for Lyme disease detection. Lyme disease is caused by the bacteria Borrelia burgdorferi (B. burgdorferi) and is transmitted to humans and... Read More

Web-Based Anatomical Board Database Application

34035 – Fully-functional database system enables institutions to track and manage human cadaver donations. Researchers at the University of Central Florida’s College of Medicine have developed a customizable web-based application for managing cadaver donations and providing a registry of the Willed-Body Program. The Willed-Body Program enables residents of their respective states to donate their... Read More

An example diagram of the noninvasive, portable, aspiration detection system.

Portable Breath Gas Analysis System

34004 – Low-cost, noninvasive, point-of-care system quickly detects aspiration in dysphasia patients. Researchers at the University of Central Florida have invented a fast and simple way to quickly detect pulmonary aspiration in patients with dysphasia (difficulty swallowing) or other conditions that put them at risk for aspiration-related illnesses. Pulmonary aspiration occurs when people inhale... Read More

Diagram of a MINI system for wireless neural recordings. The 1000-ch system on a silicon die consists of a pillar electrode array, embedded integrated circuits for signal amplification and processing, and backplane planar coils and capacitors for wireless telemetry and power.

Neural Interface System

34017 – New approach to building scalable brain-machine interface systems may enable widespread use of wireless, remotely-powered neural interface implants in patients needing prostheses. Researchers at the University of Central Florida have designed an innovative brain-machine interface (BMI) system that can enable throughput of 1,000 or more parallel recordings to repair human cognitive or... Read More

Figure 1. An isometric, conceptual view of a toy bear with integrated data sensors.

Novel System for Capturing, Quantifying and Analyzing Therapy Interactions

33898 – Innovation aids counselors in diagnosing and treating a child’s behavioral disorder using quantifiable evidence from play therapy sessions. UCF researchers have designed a system that mental health professionals can use to capture and track quantifiable data about a child’s development and behavior during therapy sessions. The Science of Play system works in real time, monitoring... Read More

Figure (a) shows a schematic representation of chiral light-matter interaction between left-circularly polarized (LCP) and (s) enantiomer; (b) shows a top view of one uncoated sample and cross-section view of one polymer-coated substrate embedding the chiral molecule; (c) shows a representation for the optical characterization.

Molecular Chirality Detection Technique using Hybrid Plasmonic Substrates

33902 – System offers low-cost methods for efficiently and accurately detecting low levels of left- and right-handed enantiomers of drugs seeking FDA approval University of Central Florida researchers have designed a system that can accurately identify the chirality of drugs, proteins, DNA and other molecules at lower detection limits than conventional detection systems. With the ability to... Read More

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

Antimicrobial Compositions for Treating Clostridium Infections

33842 – New methods using puupehenone compounds may kill or prevent Clostridium difficile infections. A UCF researcher has developed new methods for using puupehenone compounds to possibly treat illnesses caused by Clostridium bacterial strains, such as C. difficile. Puupehenone is a marine natural product excreted by some species of sponges and coral as a defense mechanism. The UCF invention may... Read More

Low-Cost Test for Distinguishing Between Real and Synthetic Urine

34002 – Test for identifying fake urine when screening workers for illicit drugs UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external... Read More

Profiles of gold (III) macrocycles that are active against Mtb and Mab.

Methods for Using Gold (III) Compounds to Potentially Treat Tuberculosis (TB)

33894 – Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab). The identified compounds... Read More

Novel Compounds to Treat Malaria May Also Alleviate Parasite Drug Resistance

32882 – New Marine-Based Compounds and Aurora Kinase Inhibitors May Effectively Combat Malaria UCF researchers have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs. The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial... Read More

Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays (MEAs) with Spin-Coated Insulation and Functional Electrospun 3D Scaffolds

33871 – New MEA fabrication technology enables the development of rapid assays with 3D cell-based biosensors for toxicity testing, disease modeling and optical/electrical stimulation of cell types. Exploded view of the 3D MEA: 3D microtowers, metallization, laminate insulation and containment culture well with a close-up of 10 recording sites per patch. Fully functional for “disease in a... Read More

Figure 1. Schematic view of the imaging operational concept.

Cost-Effective Imaging System Uses RF Magnetic Field and Loop Bolometer Array to Produce MRI-Quality Images

33853 – New system can generate detailed images of internal body structures and identify defects embedded in electronic circuits UCF researchers have designed a new imaging system that captures detailed, 3D views of an object’s internal structures and is more affordable, compact and transportable than other systems. The invention is safe to use for both medical and scientific applications, since... Read More

Diagram (a) illustrates the new UCF 3D-printing technique used to produce 3D-printed porous scaffolds for cell culture. Image (b) shows the honeycomb design of scaffolds and the actual appearance of scaffolds with different processing routes after recovery from a gelatin bath. Recovered prints were immersed in cell culture media to reveal pore formation with the existence of bubbles inside the struts. Scale bars are 10mm.

3D-Printing Technique for Creating Biomaterial Structures with Tailored Hierarchical Porosity

33859 – Novel printing technique enables the production of custom porous 3D printed biomaterial scaffolds. UCF researchers have developed a new 3D printing technique to produce biomaterial scaffolds with controlled porosity. This technique enables the design and production of 3D printed structures with pores throughout the scaffold, providing additional sites for seeded cells to adhere and grow. ... Read More

Prostate cancer C4-2B cells on different stiffness CA scaffolds. Mineralization increases with stiffness.

3D Biomaterial Scaffolds Mimic Tumor Microenvironment and Enable Drug Screening for Personalized Cancer Therapies

33849 – New 3D biomaterial scaffold enables testing of chemotherapies before administering to patients Researchers at UCF and the Mayo Clinic are developing a diagnostic tool for predicting patient outcome in response to a particular cancer treatment. The tool consists of biomaterial scaffolds that mimic the in vivo 3D structure of the tumor microenvironment and can be used as an in vitro platform... Read More

Diagnostic Kit Detects Pathogenic Microorganisms Based on Electric Signatures

33854 – Novel kit uses electrophysiology to help clinicians identify and effectively treat bacterial diseases in plants, animals and humans UCF researchers have developed a novel diagnostic kit for quickly identifying microorganisms and detecting live versus dead cells, based on their electrical activity. The invention can also be used to determine whether a cell is actively growing,... Read More

UCF’s Young Adult and Adolescent Male Health Behavior Indicators Scale enables health organizations to gain deeper insight into the health-related attitudes, perceptions and experiences of YAAM populations and the health disparities that they encounter.

Assessment Tool Identifies Male Behavior and Attitudes Toward Healthcare

33783 – Survey Tool Enables Researchers to Capture Critical Data about Promoting Health Services to Young Adult Males UCF researchers have developed a valuable survey tool that can help organizations improve their healthcare service and delivery systems aimed at young adult and adolescent males (YAAMs). With the Young Adult and Adolescent Male Health Behavior Indicators Scale, health... Read More

Decision Support System Helps Hospitals Prevent Heart Failure Readmissions

33648 – Low-cost, innovative support tool enables care managers to implement interventions that prevent readmissions and improve the health outcomes of patients with heart failure UCF researchers have invented a decision support tool for enhancing patient care and reducing hospital readmissions related to heart failure (HF). The innovative support tool identifies and analyzes patient-centric human... Read More

Figure 1. Left image: Dotted red lines show the abdominal region boundaries on the left. Right image: A thin discontinuous muscle wall (dotted blue curve) separates VAT and SAT.

First Automated System to Quantify White and Brown Adipose Tissue at the Whole-Body, Body-Region and Organ Levels

33690 – Innovative system enables clinicians to better assess health risks of obese patients by accurately identifying and quantifying body fats UCF researchers have developed the first automated system to provide accurate, quantitative data regarding a person’s white and brown body fat (adipose tissue) levels. The innovation enables clinicians to better assess possible health issues and risks... Read More

A sample SterilEyes application for the donning/doffing of a hazmat suit.

Real-Time Crowd-Sourced Oversight of Protective Equipment Donning/Doffing

33444 – Crowd sourced review and certifying service enables healthcare workers to have their PPE donning/doffing techniques collectively observed and reviewed in real time UCF researchers have developed a system and methods that healthcare workers, firefighters and other first responders can use to ensure that they and colleagues worldwide properly don (put on) or doff (take off) personnel... Read More

Illustration of the system capturing and identifying contaminated areas in a mock medical procedure

System Monitors Medical Procedures to Detect Sterile Field Contamination

33396 – UCF researchers have developed an automated detection system aimed at helping to prevent and reduce the number of healthcare-associated infections (HAIs) contracted during medical procedures. The new System for Detecting Sterile Field Events tracks activity during training or an actual medical procedure and identifies actions (such as contact-related events) that violate the sterile field and... Read More

Mosquitoes feeding on the Passive Insect Surveillance Sensor Device

Low-Cost Device Catches, Kills and Identifies Vectors with Infectious Diseases

33502 – According to the World Health Organization, vector-borne diseases account for more than 17 percent of all infectious diseases, causing more than 1 million deaths annually. Confirmed cases of Dengue fever (DENV), Zika (ZIKV) or chikungunya (CHIKV) in the Americas over the past few years now pose a heightened risk for epidemics in the U. S., as well as in the traditional endemic areas like... Read More

Breakthrough Optical Blood Coagulation Monitor Provides Real-time Feedback

31064 – Life-saving device continuously checks a patient’s blood clotting status during and after surgery UCF researchers have developed a breakthrough early-detection system that helps detect life-threatening blood clots during and after a medical procedure. Conventional laboratory blood coagulation tests are time-intensive, requiring blood to be drawn, processed and analyzed. The UCF real-time... Read More

Schematic representation of the fabrication and use of the ISE.

Ready-to-Use Paper Ion Sensor for On-Site Analysis

33425 – Ion-selective electrodes (ISEs) are highly important for ion detection. Paper-based ISEs are a simple, low cost, and disposable alternative to conventional solid-contact ISEs. However, widespread use of paper-based ISEs has been limited due to poor detection limits (in the micromolar range), reliability, and selectivity. UCF researchers have developed novel ultra-sensitive paper-based ISEs... Read More

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