UCF Office of Research
Office of Technology Transfer
|
12201 Research Parkway, Suite 501 |
Orlando, FL 32826
Phone: 407.882.0340 | Fax: 407.823.3299
Healthcare
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Exosome-Based RNAi Delivery for Anti-Cancer and Anti-Viral Therapy
11510 – Researchers at the University of Central Florida have developed an exosome-based approach for treating cancer and viral infections. The exosomes deliver gene-silencing molecules or protein inhibitors such as RNA interference (RNAi) or antibodies, respectively. Because exosomes are endogenous vesicles, this approach may limit immunogenicity and toxicity. For anti-cancer... Read More
Device Cuts and Crimps Tissue for Single-Step Meatotomy
2021-101 – The University of Central Florida invention is a multi-functional surgical device for performing meatotomy procedures without needing additional devices. The device includes a centrally-located blade, flanked on both sides by ridged grooves, allowing it to simultaneously crimp and cut tissue. With the device, the meatotomy procedure can occur in a single step which can improve... Read More
Antimalarial Compounds Combat Drug-Resistant Parasites
11434 – Researchers at the University of Central Florida have developed potent compounds for fighting chloroquine-resistant malaria-causing parasites. The low nanomolar compounds were effective against chloroquine-resistant Dd2 strains of Plasmodium falciparum parasites in vitro and completely cured malaria infection in vivo. The Plasmodium falciparum parasite has developed resistance to... Read More
Polyamine Transport Inhibitors to Activate an Anti-Tumor Immune Response
11057 – Researchers at the University of Central Florida and the Lankenau Institute for Medical Research have synthesized new anti-cancer small molecules that block polyamine uptake and activate the anti-tumor immune response. Many tumors require high levels of polyamines to support their growth and survival. Additionally, high levels of polyamines can suppress the immune system, allowing... Read More
Topical Treatment to Promote Hair Growth
7604 – Researchers at the University of Central Florida are developing a topical treatment to promote hair growth. The active compound is a heterocyclic pyrimidine known as NBI-18. The researchers previously found that NBI-18 stimulated the proliferation of neural stem cells. They hypothesized that NBI-18 could restore hair growth by increasing cell proliferation of endogenous stem cells... Read More
User-Accessible Tissue Sample Image Database System
7043 – A University of Central Florida researcher has developed a tissue image database system that enables users to search for and match images based on the presence of a target molecule, internal anatomical structure, or both. The patented system provides powerful tools that can help to expand and support medical and scientific research and informational exchange. For example, a user... Read More
Tactile Telepresence for Isolated Patients (TTIP)
11610 – The University of Central Florida invention comprises tactile-visual systems and methods for social interactions between isolated patients (for example, those with COVID-19) and remote visitors such as loved ones, family members, friends, or volunteers. A primary goal is to provide the isolated patient and the remote visitors with a visual interaction augmented by touch—a... Read More
Preserve Nucleic Acids in Water Samples Without Refrigeration
2021-100 – The University of Central Florida invention is a method for preserving nucleic acids in biological materials. It includes a dry nucleic acid preservative reagent that can be used on-site without refrigeration or freezing. The reagent is shelf-stable and does not interfere with the subsequent nucleic acid extraction. Additionally, due to the dry formulation, it can be used with... Read More
Customizable 3D Microelectrode Array with Tri-Modal Functionalities
2021-109 – The University of Central Florida invention is a polymer and metal-based microfabrication technology for 3D microelectrode arrays (3D MEAs). The device incorporates “tri-modal functionality” for obtaining simultaneous data sets comprising electrical, optical and microfluidic markers from a variety of electrogenic cellular constructs. 3D MEAs are the next-generation interfaces for... Read More
Pneumatic-Hydraulic Hybrid Variable Stiffness Design for Ankle-Foot Prostheses
11643 – The University of Central Florida invention relates to a new design for ankle-foot prostheses that incorporates a hybrid closed loop pneumatic and hydraulic system to control the level of stiffness and energy return timing during walking.
Chaperonin-Containing TCP-1 Inhibitors for the Treatment of Cancer
2021-065 – No summary available
Convenient, Self-Sterilizing Rollable Face Mask for Everyday Use
2021-057 – Researchers at the University of Central Florida have designed a face mask that conveniently rolls into a necklace-like device that also sterilizes the mask when not in use. The World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) strongly recommend wearing a mask to prevent infections and to mitigate the spread of contagious diseases such... Read More
CD25 Targeted IL-2 Therapy for Respiratory Viral Infections
11577 – Researchers at the University of Central Florida have developed a new approach for modulating the inflammatory response during acute respiratory viral infections. This approach generates a robust inflammatory response against the viral infection while minimizing damaging inflammation and immunopathology. Infections by respiratory viruses, such as influenza viruses and... Read More
Nanoceria-Based Rapid Acting Disinfectant (RAD) Spray
11585 – The University of Central Florida invention is a nanoceria-based solution for disinfectant use. Rapid Acting Disinfectant (RAD) Spray is a solution that can curb transmission of COVID-19 via contact with surfaces in a manner that is not currently available and is unique as a disinfectant spray and temporary film. Early studies have shown that these viruses can live between two to... Read More
Plasmonic Organic Electrochemical Transistors (POECTs) for Highly Enhanced Sensing
11649 – The University of Central Florida invention is a new type of organic electrochemical transistor (OECT) called the plasmonic OECT (POECT). The invention leverages the near-field effect of plasmonics to increase the sensitivity of OECTs. Organic electrochemical transistors (OECTs) marked a rapid growth in recent years due to their attractive applications in biosensing,... Read More
Method and Device for Pathogen or Antibody Detection Using Unmodified Signaling Substances With or Without Unlabeled Detection Reagents
11472 – The University of Central Florida invention relates to methods for detecting a target pathogen or antibody in biological samples. The disclosed methods include three embodiments and do not require labeling or conjugating of the detection reagent with the signaling molecule or substance to generate detectable signals. The first embodiment relates to using an unlabeled antibody... Read More
A 3D Printed, Self-Insulated, High-Throughput 3D Microelectrode Array
11591 – The University of Central Florida invention is a novel two-step, makerspace-based microfabrication strategy for creating high-throughput (HT), self-insulated 3D microelectrode arrays (MEAs). Microstereolithography (μSLA)-based 3D printing technology not only allows for the realization of 3D microelectrode geometries but also enables the monolithic integration of all components of... Read More
Complex Refractive-Index Imaging by Iterative Optical Diffraction Tomography
11459 – Researchers at the University of Central Florida have invented a technique for capturing and reconstructing images of phase objects with greater accuracy and quality than conventional optical diffraction tomography (ODT) inversion methods. Example objects include transparent samples such as biological cells, tissues and optical fibers with high contrast, complicated structure, or... Read More
Percutaneous Tool Guide Template and Insert
11601 – The University of Central Florida invention is a guide hole design that enables accurate and precise needle targeting while minimizing the change in dynamic characteristics. As a result, the biopsy needle can fire at the designed speed, leading to a successful intervention. Percutaneous intervention procedures are employed in numerous surgical methods involving needle puncture... Read More
A Color Changing Silk Patch for Visible Reactive Oxygen Species (ROS) Detection
11493 – The University of Central Florida invention describes a method of detecting reactive oxygen species (ROS) levels in a wound by engineering a color‐changing patch that could be applied as a quick and visible indicator of oxidative stress. The majority of ROS are released by neutrophils and macrophages during the inflammatory phase of healing to kill foreign pathogens that may have... Read More
Skull-Mounted Robotic Guide
11618 – The University of Central Florida invention is a compact robotic system that can enhance surgical precision during orthognathic (corrective jaw) surgery. The device, which complements a surgeon’s free hand expertise, can be directly mounted onto a patient’s skull to assist the surgeon in precisely repositioning the jawbone during the procedure.
Combination Drug Treatment to Increase Neurogenesis for Neurological Disorders
11616 – The University of Central Florida invention relates to a combination therapy to promote neuroregeneration consisting of 1) MS-818 to increase endogenous neural stem cells and 2) non-steroidal anti-inflammatory drugs to suppress inflammation
Systems Offer Centralized Mechanism for Evaluating the Completeness and Accuracy of Patient Files in Medical Databases
11503 – Researchers at the University of Central Florida have developed technologies for quantitatively evaluating, tracking and managing patient medical records. With unique methodologies and statistical analyses, the technologies provide tools for assessing the strength, completeness, consistency, and accuracy of patient electronic medical records (EMRs) in one or more databases. One of... Read More
Mouse Home Cage Programmable Food Access Controller
34561 – The University of Central Florida invention relates to an automated food access control device that can be used with standard laboratory mice cages. The device consists of a microcontroller, a servomotor, and a moveable food hopper.
Procedure for Determining DNA barcodes for Efficient Species Categorization Using Nanopore Translocation
34583 – The University of Central Florida invention relates to methods for measuring DNA barcodes using single or multi‐nanopore platforms. Barcodes are calculated by observing the detail motion of the dsDNA segments in between the barcodes using Brownian dynamics simulation.
A Viral Protein Conferring Increased Sensitivity of Cancer Cells to Chemotherapeutic Agents
34240 – The University of Central Florida invention relates to the development of a combination therapy to increase the sensitivity of cancer cells to chemotherapy. The “sensitizing agent” is a small viral protein known as the V protein. As a feasibility study, expression of the V protein in tissue culture cells increased the sensitivity of cancer cells to a range of chemotherapeutic... Read More
Two-Stage Method for Reliable Routine Cancer Screening
34509 – The University of Central Florida invention relates to a two-step, blood-based cancer screening test. The first step screens for elevated levels of Fibroblast Growth Factor 19 (FGF19) via a standard enzyme-linked immunosorbent assay (ELISA). Patients with elevated levels of FGF19 continue with a second/follow-up test using oral cholestyramine as a “suppression” drug to verify that... Read More
Targeting Cancer Stem Cells with RNAi
34329 – Researchers at the University of Central Florida are developing RNA interference (RNAi)-based therapies for increasing the sensitivity of cancer stem cells to chemotherapy. Cancer stem cells are a specialized subset of tumor cells that are often resistant to cancer therapy. This technology targets the expression of the embryonic stem cell genes NANOG or OCT4 which are expressed in... Read More
Makerspace Fabrication Technology for Faster, Precise Production of 3D Metal Microelectrode Arrays (MEAs)
34429 – Researchers at the University of Central Florida have developed a simple, inexpensive solution for fabricating 3D metal microelectrode arrays (MEAs) and microneedle platforms. Compared to current technologies, the UCF makerspace technology overcomes issues such as brittleness, high expense, complexity, and unrepeatable processes. As a result, the invention offers cost-... Read More
Highly Porous Frozen Films Enable Easier Cell Seeding, Cell Recovery and Imaging as Biomaterial Substrates
34371 – University of Central Florida researchers have developed biomaterial substrates that combine the benefits of 2D and 3D culture platforms while limiting the drawbacks. The UCF frozen films (FFs) are highly porous thin films with micron-scale porosity and fibrous struts. As biomaterial substrates, the FFs better replicate in vivo conditions and enable cells to attach quicker than 2D... Read More
3D Microelectrode Array for Optical and Electrical Probing of Electrogenic Cells
34513 – Researchers at the University of Central Florida have developed methods for microfabricating and assembling three-dimensional microelectrode arrays (3D MEAs) based on a glass-stainless steel platform. The technology uses non-traditional “makerspace microfabrication” techniques that enable the cost-effective fabrication of a device using biocompatible materials. 3D MEAs provide... Read More
Exosomal NANOG DNA as a Diagnostic Cancer Marker
34174 – The University of Central Florida invention relates to the use of NANOG exosomal DNA as a diagnostic cancer marker. Specifically, the marker is a 22bp insert in the 3’UTR of the NANOG pseudogene, NANOGP8. Exosomes are extracellular microvesicles (30-100 nm) released by almost all types of cells upon fusion of the multi-vesicular body with the plasma membrane. Known for their role in... Read More
Direct Reprogramming of Mesenchymal Stems Cells to Neural Stem Cell-Like Cells
34445 – Researchers at the University of Central Florida have developed a xeno-free and transgene-free method for reprogramming mesenchymal stem cells to neural stem cell-like cells. Neural stem cells are difficult to obtain for therapeutic use due to their location in the brain. As an alternative, multipotent mesenchymal stem cells are a potential source of neural stem cells, but must... Read More
Polyamine Transport Inhibitors as Antiviral Agents
34459 – Researchers at the University of Central Florida and Boston University are developing polyamine transport inhibitors for use as antiviral compounds. Polyamines are required for a variety of viral processes including replication, protein synthesis, and virus-host interactions. Many viruses, including coronaviruses, have been shown to be sensitive to polyamine depletion. While... Read More
Fungus-Derived Compounds to Fight Drug-Resistant Malaria
34250 – Researchers at the University of Central Florida and the University of Oklahoma have identified fungus-derived compounds for developing treatments against drug-resistant species of Plasmodium. Compounds collected from a large library of diverse fungi (including pure compounds and extracts) may enable scientists to target new cellular structures of malaria-causing parasites such as... Read More
Novel Carbapenems to Combat Drug-Resistant Mycobacteria
33910 – Researchers at the University of Central Florida and Southern Methodist University have developed novel carbapenem antibiotics that exhibit enhanced activity against drug-resistant strains of mycobacterial species, such as Mycobacterium tuberculosis (Mtb) and Micobacterium abscessus (Mabs). The narrow-spectrum carbapenems selectively target mycobacterial L, D-transpeptidases. In... Read More
Energy-Efficient, Real-Time Variable Stiffness Ankle-Foot Prosthesis
34461 – Researchers at the University of Central Florida have developed an innovative, bio-inspired ankle-foot prosthesis that can automatically adjust its ankle stiffness to accommodate different activities. For example, the device can quickly adapt to walking conditions such as inclines, declines, and uneven soft or hard surfaces. The novel prosthesis uses a highly efficient energy... Read More
CRISPR-Based Imaging System Detects Target Gene Loci in Live Cells
34082 – Researchers at the University of Central Florida and the University of Massachusetts have developed a CRISPR-based system for detecting DNA repeat expansion sequences—genetic mutations that cause diseases such as amyotrophic lateral sclerosis (ALS). The CRISPR Arrayed Repeat Detection System (CARDS) can detect multiple mutated genes simultaneously in a single assay.... Read More
Edible Confections to Reduce Cough- or Sneeze-Induced Pathogen Transmission
34433 – Researchers at the University of Central Florida have developed a composition of edible ingredients that may reduce the transmissibility of airborne pathogens from person to person. Airborne-transmitted pathogens often spread through close contact between humans via respiratory functions. This includes sneezing, coughing, talking and breathing. For example, coughing causes a... Read More
Nano-Coating Captures and Kills Viruses on Personal Protective Equipment (PPE)
34370 – Polymer-based, antiviral coating may kill pathogens on face masks and gloves to prevent surface-to-surface contamination Researchers at the University of Central Florida have developed an innovative nano-coating designed to capture and kill viruses on PPEs and other medical equipment. For example, the invention may be used to target SARS-CoV-2, the virus that causes the COVID-19 disease.... Read More
COVID-19 Training Cards Offer Easy Access to Key Safety Information
34378 – New training cards provide CDC-recommended steps for fighting the spread of COVID-19 Researchers at the University of Central Florida have developed educational training cards about COVID-19 and ways to stay safe from the disease. The deck of 52 cards provides key information including how the disease spreads and CDC-recommended instructions for preventing and transmitting the disease... Read More
Capsule-Based System for Object Segmentation Offers Accuracy at Less Cost
34138 – New SegCaps deep learning architecture enables more cost-effective segmentation of medical images. Researchers at the University of Central Florida have developed an innovative capsule-based deep learning system that requires far less parameterization to perform object segmentation more accurately and efficiently than state-of-the-art convolutional neural networks (CNNs) such as U-Net. The... Read More
Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy
34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More
Novel System for Automatically Diagnosing Pancreatic Intraductal Papillary Mucinous Neoplasms
34177 – New diagnostic tool speeds the process of detecting and analyzing precancerous pancreatic cysts. Researchers at the University of Central Florida and the Mayo Clinic have developed an automated system that enables radiologists to detect and assess the cancer risk of pancreatic cysts faster and more effectively than using conventional MRI technology and radiographic guidelines. The cysts,... Read More
Novel Ankle Prosthetic Module Maximizes the Propulsion Efficiency of Passive Prostheses
34171 – Real-time module enables passive ankle prosthesis to control and release stored energy for optimal propulsion. Researchers at the University of Central Florida have developed a device with a unique learning algorithm to maximize the propulsion efficiency of passive prostheses used by individuals with transtibial (below-knee) amputations. The UCF real-time adjustable energy-releasing device... Read More
4D Biosensors for Lab-On-A-Chip and Wearable Sensor Applications
34078 – Innovative 4D biosensor technology with shape-memory recovery enables integration with implantable systems for electrical measurements. Researchers at the University of Central Florida have developed a novel 4D biosensor for lab-on-a-chip and wearable sensor applications that is more cost-effective and easier to manufacture than current technologies. Made of dynamic, stretchable, packaged... Read More
Tactile Display Apparatus for Palpation Simulation and Telemedicine
34063 – Innovative training device enables medical students to experience the near-real sensation of touch, similar to human palpation. Researchers at the University of Central Florida have designed a haptic training device that medical students can use to better distinguish between normal and abnormal lumps in the body. By providing the sensation of touch and the ability to vary the size and... Read More
New Approach for Determining Nanomaterial (NM) Biodistribution in the Body Offers an Alternative to Animal Testing
34037 – System with predictive computer modeling enables nanomaterial drug screening tests that effectively measure NM-cell interactions in vivo. Researchers at the University of Central Florida have developed a new system to quantify and accurately predict the biodistribution of nanomaterials (NMs) in the body, reducing the need for animal studies. Using a novel quantitative fluorescence-based in... Read More
Novel Syringe for One-Step RNA/DNA Purification and Medical Diagnosis
34133 – Integrated syringe combines blood sample collection and nucleic acid preparation functions to speed diagnostic testing for infectious diseases. Researchers at the University of Central Florida have designed an innovative syringe that can simultaneously draw a patient’s blood and extract/purify nucleic acids from the sample. Thus, a simple blood draw results in a prepared sample ready for... Read More
Glass-Air Optical Fiber Imaging for Accurate, Real-Time Views of Biological Objects
34029 – New approach can transmit artifact-free images of cell structures in vivo despite temperature fluctuations and optical fiber bending. Researchers at the University of Central Florida have developed a lensless fiber-optic imaging system that overcomes the expense and complications associated with existing multicore and multimode fiber-based imaging systems (MCFs, MMFs). More robust, compact... Read More
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