Healthcare

1-50 of 65 technologies within Healthcare RSS ATOM

PCR-Based Blood Test for Detecting Mycobacterium Infection in Inflammatory Bowel Disease Patients

30555 – Researchers at the University of Central Florida have developed a diagnostic test for detecting Mycobacterium avium subspecies paratuberculosis (MAP). MAP infections are linked to inflammatory bowel diseases (IBDs), such as Crohn’s disease. The exact cause of IBD is not known, and there are likely multiple etiologies for IBD in addition to MAP infection. Antibiotics are frequently... Read More

CRISPR-Based Imaging System Detects Target Gene Loci in Live Cells

34082 – Researchers at the University of Central Florida and the University of Massachusetts have developed a CRISPR-based system for detecting DNA repeat expansion sequences—genetic mutations that cause diseases such as amyotrophic lateral sclerosis (ALS). The CRISPR Arrayed Repeat Detection System (CARDS) can detect multiple mutated genes simultaneously in a single assay.... Read More

The images compare the flight of respiratory droplets after a simulated sneeze (horizontal velocity versus vertical velocity). Shown are instantaneous velocity contours of saliva, cornstarch and saliva, and mask test cases 185ms after the event starts.

Edible Confections to Reduce Cough- or Sneeze-Induced Pathogen Transmission

34433 – Researchers at the University of Central Florida have developed a composition of edible ingredients that may reduce the transmissibility of airborne pathogens from person to person. Airborne-transmitted pathogens often spread through close contact between humans via respiratory functions. This includes sneezing, coughing, talking and breathing. For example, coughing causes a... Read More

Example prototype of the UCF 3D-printed fingertip pediatric laryngoscope-intubation device.

3D-Printed Fingertip Pediatric Laryngoscope for Safer, Faster Intubation

34054 – New flexible device can be custom-printed to fit a child’s respiratory tract and minimize intubation trauma from surgical procedures. Researchers at the University of Central Florida have developed a combined pediatric laryngoscope and intubation medical device that facilitates tracheal intubation while reducing patient trauma. The low-cost, 3D-printed innovation is more flexible and... Read More

Schematic illustration of the UCF nano-coating.

Nano-Coating Captures and Kills Viruses on Personal Protective Equipment (PPE)

34370 – Polymer-based, antiviral coating may kill pathogens on face masks and gloves to prevent surface-to-surface contamination Researchers at the University of Central Florida have developed an innovative nano-coating designed to capture and kill viruses on PPEs and other medical equipment. For example, the invention may be used to target SARS-CoV-2, the virus that causes the COVID-19 disease.... Read More

COVID-19 Training Cards Offer Easy Access to Key Safety Information

34378 – New training cards provide CDC-recommended steps for fighting the spread of COVID-19 Researchers at the University of Central Florida have developed educational training cards about COVID-19 and ways to stay safe from the disease. The deck of 52 cards provides key information including how the disease spreads and CDC-recommended instructions for preventing and transmitting the disease... Read More

Capsule-Based System for Object Segmentation Offers Accuracy at Less Cost

34138 – New SegCaps deep learning architecture enables more cost-effective segmentation of medical images. Researchers at the University of Central Florida have developed an innovative capsule-based deep learning system that requires far less parameterization to perform object segmentation more accurately and efficiently than state-of-the-art convolutional neural networks (CNNs) such as U-Net. The... Read More

The UCF invention delivers iron to targeted tumor cells to enable ferroptosis-assisted chemodynamic therapy. Image reprinted with permission from Molecular Pharmaceutics 2019, 16, 4852−4866, DOI: 10.1021/acs.molpharmaceut.9b00737. American Chemical Society.

Conjugated Polymer Nanoparticles for Targeted Anticancer Chemodynamic Therapy

34364 – Tumor-targeting nanoparticles induce ferroptosis in cancer cells without need for external activation Researchers at the University of Central Florida have developed a tumor-targeting nanoparticle system for chemodynamic therapy (CDT). The conjugated polymer nanoparticles (CPNPs) deliver iron for CDT at the targeted tumor site. In contrast to photodynamic therapy, which requires external... Read More

The diagram provides an overview of the new system for automatically diagnosing IPMNs.

Novel System for Automatically Diagnosing Pancreatic Intraductal Papillary Mucinous Neoplasms

34177 – New diagnostic tool speeds the process of detecting and analyzing precancerous pancreatic cysts. Researchers at the University of Central Florida and the Mayo Clinic have developed an automated system that enables radiologists to detect and assess the cancer risk of pancreatic cysts faster and more effectively than using conventional MRI technology and radiographic guidelines. The cysts,... Read More

Novel Ankle Prosthetic Module Maximizes the Propulsion Efficiency of Passive Prostheses

34171 – Real-time module enables passive ankle prosthesis to control and release stored energy for optimal propulsion. Researchers at the University of Central Florida have developed a device with a unique learning algorithm to maximize the propulsion efficiency of passive prostheses used by individuals with transtibial (below-knee) amputations. The UCF real-time adjustable energy-releasing device... Read More

Figure 1. An example of a packaged device made using the invention (left) and its 4D characteristics (right).

4D Biosensors for Lab-On-A-Chip and Wearable Sensor Applications

34078 – Innovative 4D biosensor technology with shape-memory recovery enables integration with implantable systems for electrical measurements. Researchers at the University of Central Florida have developed a novel 4D biosensor for lab-on-a-chip and wearable sensor applications that is more cost-effective and easier to manufacture than current technologies. Made of dynamic, stretchable, packaged... Read More

Example diagrams of the UCF tactile display apparatus design: (a) shows an external view and (b) shows an internal view of the device.

Tactile Display Apparatus for Palpation Simulation and Telemedicine

34063 – Innovative training device enables medical students to experience the near-real sensation of touch, similar to human palpation. Researchers at the University of Central Florida have designed a haptic training device that medical students can use to better distinguish between normal and abnormal lumps in the body. By providing the sensation of touch and the ability to vary the size and... Read More

Schematic overview of the UCF approach to predict the biodistribution of nanomaterials in the body.

New Approach for Determining Nanomaterial (NM) Biodistribution in the Body Offers an Alternative to Animal Testing

34037 – System with predictive computer modeling enables nanomaterial drug screening tests that effectively measure NM-cell interactions in vivo. Researchers at the University of Central Florida have developed a new system to quantify and accurately predict the biodistribution of nanomaterials (NMs) in the body, reducing the need for animal studies. Using a novel quantitative fluorescence-based in... Read More

As shown in figures (a) and (b), the new UCF blood-sampling syringe fully incorporates a nucleic acid purification function. The graph (c) shows the effectiveness of the tool’s DNA capture. Researchers used a real-time PCR to quantify and compare the captured DNA to the original blood sample.

Novel Syringe for One-Step Purification and Medical Diagnosis

34133 – Integrated syringe combines blood sample collection and nucleic acid preparation functions to speed diagnostic testing for infectious diseases. Researchers at the University of Central Florida have designed an innovative syringe that can simultaneously draw a patient’s blood and extract/purify nucleic acids from the sample. Thus, a simple blood draw results in a prepared sample ready for... Read More

Figure 1. The graphic (a) schematically illustrates an experimental incoherent light-illuminated DCNN-GALOF imaging system without distal optics. The light source is a low-cost LED. To quantify the amount of fiber bending (b) the offset distance was measured as the distance from the end of the bent fiber to the position of the straight fiber (equal to the length of the dashed line).

System Combines Glass-Air Optical Fiber Imaging and Deep Learning to Capture Accurate, Real-Time Views of Biological Objects

34029 – New approach can transmit artifact-free images of cell structures in vivo despite temperature fluctuations and optical fiber bending. Researchers at the University of Central Florida have developed a lensless fiber-optic imaging system that overcomes the expense and complications associated with existing multicore and multimode fiber-based imaging systems (MCFs, MMFs). More robust, compact... Read More

Lyme Disease Diagnostic Test Combines the Sensitivity of PCR with the Specificity of Immunoassays

33429 – Immuno-PCR Based Approach Enables Early and Objective Diagnosis of Lyme Disease Researchers at the University of Central Florida (UCF) have developed a multiplex immuno-PCR (iPCR) based diagnostic test which improves upon currently available approaches for Lyme disease detection. Lyme disease is caused by the bacteria Borrelia burgdorferi (B. burgdorferi) and is transmitted to humans and... Read More

Web-Based Anatomical Board Database Application

34035 – Fully-functional database system enables institutions to track and manage human cadaver donations. Researchers at the University of Central Florida’s College of Medicine have developed a customizable web-based application for managing cadaver donations and providing a registry of the Willed-Body Program. The Willed-Body Program enables residents of their respective states to donate their... Read More

An example diagram of the noninvasive, portable, aspiration detection system.

Portable Breath Gas Analysis System for Detecting Pulmonary Aspiration

34004 – Low-cost, noninvasive, point-of-care system quickly detects aspiration in dysphasia patients. Researchers at the University of Central Florida have invented a fast and simple way to quickly detect pulmonary aspiration in patients with dysphasia (difficulty swallowing) or other conditions that put them at risk for aspiration-related illnesses. Pulmonary aspiration occurs when people inhale... Read More

Diagram of a MINI system for wireless neural recordings. The 1000-ch system on a silicon die consists of a pillar electrode array, embedded integrated circuits for signal amplification and processing, and backplane planar coils and capacitors for wireless telemetry and power.

Neural Interface System Enables Throughput of 1,000-Plus Parallel Recordings

34017 – New approach to building scalable brain-machine interface systems may enable widespread use of wireless, remotely-powered neural interface implants in patients needing prostheses. Researchers at the University of Central Florida have designed an innovative brain-machine interface (BMI) system that can enable throughput of 1,000 or more parallel recordings to repair human cognitive or... Read More

Figure 1. An isometric, conceptual view of a toy bear with integrated data sensors.

Novel System for Capturing, Quantifying and Analyzing Therapy Interactions

33898 – Innovation aids counselors in diagnosing and treating a child’s behavioral disorder using quantifiable evidence from play therapy sessions. UCF researchers have designed a system that mental health professionals can use to capture and track quantifiable data about a child’s development and behavior during therapy sessions. The Science of Play system works in real time, monitoring... Read More

Figure (a) shows a schematic representation of chiral light-matter interaction between left-circularly polarized (LCP) and (s) enantiomer; (b) shows a top view of one uncoated sample and cross-section view of one polymer-coated substrate embedding the chiral molecule; (c) shows a representation for the optical characterization.

Molecular Chirality Detection Technique using Hybrid Plasmonic Substrates

33902 – System offers low-cost methods for efficiently and accurately detecting low levels of left- and right-handed enantiomers of drugs seeking FDA approval University of Central Florida researchers have designed a system that can accurately identify the chirality of drugs, proteins, DNA and other molecules at lower detection limits than conventional detection systems. With the ability to... Read More

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

Non-Polyamine-Based Polyamine Transport Inhibitors to Treat Cancer and Infectious Diseases

33850 – Novel PTIs help block escape pathways of cancers treated with polyamine biosynthesis inhibitors like alpha-difluoromethylornithine (DFMO). Researchers at UCF and Sanford Burnham Prebys Medical Discovery Institute (SBPMDI) have identified novel non-polyamine-based polyamine transport inhibitor (PTI) compounds to treat cancers with high polyamine requirements. Since the compounds are not... Read More

Antimicrobial Compositions for Treating Clostridium Infections

33842 – New methods using puupehenone compounds may kill or prevent Clostridium difficile infections. A UCF researcher has developed new methods for using puupehenone compounds to possibly treat illnesses caused by Clostridium bacterial strains, such as C. difficile. Puupehenone is a marine natural product excreted by some species of sponges and coral as a defense mechanism. The UCF invention may... Read More

Low-Cost Test for Distinguishing Between Real and Synthetic Urine

34002 – Test for identifying fake urine when screening workers for illicit drugs UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external... Read More

Profiles of gold (III) macrocycles that are active against Mtb and Mab.

Methods for Using Gold (III) Compounds to Potentially Treat Tuberculosis (TB)

33894 – Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab). The identified compounds... Read More

Novel Compounds to Treat Malaria May Also Alleviate Parasite Drug Resistance

32882 – New Marine-Based Compounds and Aurora Kinase Inhibitors May Effectively Combat Malaria UCF researchers have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs. The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial... Read More

Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays (MEAs) with Spin-Coated Insulation and Functional Electrospun 3D Scaffolds

33871 – New MEA fabrication technology enables the development of rapid assays with 3D cell-based biosensors for toxicity testing, disease modeling and optical/electrical stimulation of cell types. Exploded view of the 3D MEA: 3D microtowers, metallization, laminate insulation and containment culture well with a close-up of 10 recording sites per patch. Fully functional for “disease in a... Read More

Figure 1. Schematic view of the imaging operational concept.

Cost-Effective Imaging System Uses RF Magnetic Field and Loop Bolometer Array to Produce MRI-Quality Images

33853 – New system can generate detailed images of internal body structures and identify defects embedded in electronic circuits UCF researchers have designed a new imaging system that captures detailed, 3D views of an object’s internal structures and is more affordable, compact and transportable than other systems. The invention is safe to use for both medical and scientific applications, since... Read More

Diagram (a) illustrates the new UCF 3D-printing technique used to produce 3D-printed porous scaffolds for cell culture. Image (b) shows the honeycomb design of scaffolds and the actual appearance of scaffolds with different processing routes after recovery from a gelatin bath. Recovered prints were immersed in cell culture media to reveal pore formation with the existence of bubbles inside the struts. Scale bars are 10mm.

3D-Printing Technique for Creating Biomaterial Structures with Tailored Hierarchical Porosity

33859 – Novel printing technique enables the production of custom porous 3D printed biomaterial scaffolds. UCF researchers have developed a new 3D printing technique to produce biomaterial scaffolds with controlled porosity. This technique enables the design and production of 3D printed structures with pores throughout the scaffold, providing additional sites for seeded cells to adhere and grow. ... Read More

Prostate cancer C4-2B cells on different stiffness CA scaffolds. Mineralization increases with stiffness.

3D Biomaterial Scaffolds Mimic Tumor Microenvironment and Enable Drug Screening for Personalized Cancer Therapies

33849 – New 3D biomaterial scaffold enables testing of chemotherapies before administering to patients Researchers at UCF and the Mayo Clinic are developing a diagnostic tool for predicting patient outcome in response to a particular cancer treatment. The tool consists of biomaterial scaffolds that mimic the in vivo 3D structure of the tumor microenvironment and can be used as an in vitro platform... Read More

Diagnostic Kit Detects Pathogenic Microorganisms Based on Electric Signatures

33854 – Novel kit uses electrophysiology to help clinicians identify and effectively treat bacterial diseases in plants, animals and humans UCF researchers have developed a novel diagnostic kit for quickly identifying microorganisms and detecting live versus dead cells, based on their electrical activity. The invention can also be used to determine whether a cell is actively growing,... Read More

New Local Anesthetic Solution Minimizes Injection-Related Pain and Extends Limited Lidocaine Supplies

33832 – Improved Lidocaine Formulation Minimizes Pain at Injection Site While Maintaining Effectiveness Administered in more than 1 million cutaneous surgeries per year, local anesthesia injections are viewed as a very painful part of minor surgery. Additionally, the lidocaine for such formulations is in short supply. In response to these issues, UCF researchers have developed a... Read More

UCF’s Young Adult and Adolescent Male Health Behavior Indicators Scale enables health organizations to gain deeper insight into the health-related attitudes, perceptions and experiences of YAAM populations and the health disparities that they encounter.

Assessment Tool Identifies Male Behavior and Attitudes Toward Healthcare

33783 – Survey Tool Enables Researchers to Capture Critical Data about Promoting Health Services to Young Adult Males UCF researchers have developed a valuable survey tool that can help organizations improve their healthcare service and delivery systems aimed at young adult and adolescent males (YAAMs). With the Young Adult and Adolescent Male Health Behavior Indicators Scale, health... Read More

Decision Support System Helps Hospitals Prevent Heart Failure Readmissions

33648 – Low-cost, innovative support tool enables care managers to implement interventions that prevent readmissions and improve the health outcomes of patients with heart failure UCF researchers have invented a decision support tool for enhancing patient care and reducing hospital readmissions related to heart failure (HF). The innovative support tool identifies and analyzes patient-centric human... Read More

Figure 1. Left image: Dotted red lines show the abdominal region boundaries on the left. Right image: A thin discontinuous muscle wall (dotted blue curve) separates VAT and SAT.

First Automated System to Quantify White and Brown Adipose Tissue at the Whole-Body, Body-Region and Organ Levels

33690 – Innovative system enables clinicians to better assess health risks of obese patients by accurately identifying and quantifying body fats UCF researchers have developed the first automated system to provide accurate, quantitative data regarding a person’s white and brown body fat (adipose tissue) levels. The innovation enables clinicians to better assess possible health issues and risks... Read More

A sample SterilEyes application for the donning/doffing of a hazmat suit.

Real-Time Crowd-Sourced Oversight of Protective Equipment Donning/Doffing

33444 – Crowd sourced review and certifying service enables healthcare workers to have their PPE donning/doffing techniques collectively observed and reviewed in real time UCF researchers have developed a system and methods that healthcare workers, firefighters and other first responders can use to ensure that they and colleagues worldwide properly don (put on) or doff (take off) personnel... Read More

Illustration of the system capturing and identifying contaminated areas in a mock medical procedure

System Monitors Medical Procedures to Detect Sterile Field Contamination

33396 – UCF researchers have developed an automated detection system aimed at helping to prevent and reduce the number of healthcare-associated infections (HAIs) contracted during medical procedures. The new System for Detecting Sterile Field Events tracks activity during training or an actual medical procedure and identifies actions (such as contact-related events) that violate the sterile field and... Read More

Mosquitoes feeding on the Passive Insect Surveillance Sensor Device

Low-Cost Device Catches, Kills and Identifies Vectors with Infectious Diseases

33502 – According to the World Health Organization, vector-borne diseases account for more than 17 percent of all infectious diseases, causing more than 1 million deaths annually. Confirmed cases of Dengue fever (DENV), Zika (ZIKV) or chikungunya (CHIKV) in the Americas over the past few years now pose a heightened risk for epidemics in the U. S., as well as in the traditional endemic areas like... Read More

Breakthrough Optical Blood Coagulation Monitor Provides Real-time Feedback

31064 – Life-saving device continuously checks a patient’s blood clotting status during and after surgery UCF researchers have developed a breakthrough early-detection system that helps detect life-threatening blood clots during and after a medical procedure. Conventional laboratory blood coagulation tests are time-intensive, requiring blood to be drawn, processed and analyzed. The UCF real-time... Read More

Schematic representation of the fabrication and use of the ISE.

Ready-to-Use Paper Ion Sensor for On-Site Analysis

33425 – Ion-selective electrodes (ISEs) are highly important for ion detection. Paper-based ISEs are a simple, low cost, and disposable alternative to conventional solid-contact ISEs. However, widespread use of paper-based ISEs has been limited due to poor detection limits (in the micromolar range), reliability, and selectivity. UCF researchers have developed novel ultra-sensitive paper-based ISEs... Read More

The Dementia and Delirium Analysis Research Tool

33410 – An easy-to-use, accessible questionnaire that both clinicians and caregivers can use with dementia and delirium patients Currently, screenings for delirium and dementia are performed separately and administered by a trained professional. However, this process is inconvenient and time consuming for both the clinician and the patient, often leading to misdiagnoses in busy clinical settings... Read More

A schematic showing the mechanisms by which a NC coating can prevent osteolysis by scavenging free radicals, suppressing immune reaction locally and inhibiting corrosion, in accordance with an embodiment.

New Coating for Prosthetic Implants Helps to Reduce Inflammation and Bone Loss

33321 – UCF researchers have invented a cerium oxide based coating with anti-inflammatory/anti-oxidant properties that may delay or prevent osteolysis by reducing inflammation and the presence of free radicals while restoring the environment’s electrochemical balance. The American Academy of Orthopedic Surgeons has projected the number of annual primary total hip joint replacement surgeries to... Read More

Block diagram of the experiment used to determine the emission spectra of the samples

Technique for Tagging Therapeutically Relevant Compounds for Tracking and Evaluation Using Infrared Excitation Sources

31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Depiction of layered structure of skin and the attenuation of incident light on the skin by various phenomena such as absorption and scattering.

Non-Invasive Sensor for Determining Blood-Sugar Levels in Diabetics and Characterizing Materials

30733 – Integrated sensor characterizes optically dense materials by distinguishing the scattering and absorption coefficients of the materials from the incident light. Non-invasive monitoring of various patients’ parameters, such as glucose concentrations, offers many advantages over invasive measurements. Patients could monitor themselves intermittently or continuously, without the need to... Read More

Timeline of exposure of a primary retinal neuron culture to treatment with cerium oxide nanoparticles

Protection of Mammalian Cells Through the Inhibition of Reactive Oxygen Species Utilizing Cerium Oxide Nanoparticles

30812 – A composition of ceria oxide nanoparticles and their biological applications for the protection of mammalian cells against reactive oxygen species, with additional specifications for the treatment of retinal neurons against light-induced degeneration. Light-induced retinal degeneration and age-related macular degeneration (AMD) are two common medical conditions which lead to sight... Read More

Head mounted brain stimulation medical device

Brain Surgery: Improvement of Deep Brain Stimulation Methods, Systems, and Devices

30314 – Methods, systems, and devices for enhancing both efficacy and efficiency of Deep Brain Stimulation – electrical stimulation known to inhibit symptoms of neurological diseases, disorders, and the like, such as tremors in Parkinson’s disease; and to substantially reduce power demands for Deep Brain Stimulation. Deep Brain Stimulation (DBS) is a form of brain surgery used to treat several... Read More

Perspective view of a first preferred embodiment of the novel probe and receiver device for simultaneous acquisition of spatial and spectral OCT (SI-OCT)

Simultaneous Spatial Imaging and Spectral Sensing for the Diagnosis of Cervical and Skin Cancers

30450 – A probe that simultaneously performs optical coherence tomography (OCT) and spectral analysis using back reflected light The present invention provides a tunable source of low-coherence light to simultaneously conduct spatial imaging and spectral sensing for tissue diagnosis. It offers a real time three dimensional colposcopy diagnosis and the detailed guidance to physically biopsy... Read More

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