Healthcare

Found 48 technologies within Healthcare RSS ATOM

Amino Acid Import Inhibitors as Antiproliferative Agents

33949 – New compounds that focus on depriving cells of key nutrients may be useful as anticancer and anti-infective agents. Researchers at UCF and the Torrey Pines Institute for Molecular Studies have identified new compounds to inhibit the growth of human cancers and parasitic infections through nutrient deprivation. The compounds inhibit the import of large neutral amino acids such as leucine... Read More

Non-Polyamine-Based Polyamine Transport Inhibitors to Treat Cancer and Infectious Diseases

33850 – Novel PTIs help block escape pathways of cancers treated with polyamine biosynthesis inhibitors like alpha-difluoromethylornithine (DFMO). Researchers at UCF and Sanford Burnham Prebys Medical Discovery Institute (SBPMDI) have identified novel non-polyamine-based polyamine transport inhibitor (PTI) compounds to treat cancers with high polyamine requirements. Since the compounds are not... Read More

Antimicrobial Compositions for Treating Clostridium Infections

33842 – New methods using puupehenone compounds may kill or prevent Clostridium difficile infections. A UCF researcher has developed new methods for using puupehenone compounds to possibly treat illnesses caused by Clostridium bacterial strains, such as C. difficile. Puupehenone is a marine natural product excreted by some species of sponges and coral as a defense mechanism. The UCF invention may... Read More

Low-Cost Test for Distinguishing Between Real and Synthetic Urine

34002 – Test for identifying fake urine when screening workers for illicit drugs UCF researchers have invented a test for determining whether a human urine sample is authentic or synthetic. The invention offers a possible low-cost solution to a growing problem in which people try to cheat job-related drug tests by submitting fake (synthetic) urine samples. Currently, employers must use external... Read More

Profiles of gold (III) macrocycles that are active against Mtb and Mab.

Methods for Using Gold (III) Compounds to Potentially Treat Tuberculosis (TB)

33894 – Gold-Complexed Compounds May Effectively Inhibit the Growth of Replicating Mycobacterium tuberculosis and Mycobacterium abscessus Pathogens Researchers at UCF and the University of the Witwatersrand, Johannesburg have identified gold (III) compounds that demonstrate antimicrobial activity against Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mab). The identified compounds... Read More

Novel Compounds to Treat Malaria May Also Alleviate Parasite Drug Resistance

32882 – New Marine-Based Compounds and Aurora Kinase Inhibitors May Effectively Combat Malaria UCF researchers have identified new compounds that may treat malaria infections more effectively than current anti-malarial drugs. The malaria parasite, Plasmodium falciparum, has developed resistance to most anti-malarial treatments, including chloroquine and artemisinin. Since the UCF anti-malarial... Read More

Fabrication and Characterization of 3D Printed, 3D Microelectrode Arrays (MEAs) with Spin-Coated Insulation and Functional Electrospun 3D Scaffolds

33871 – New MEA Fabrication Technology Enables the Development of Rapid Assays with 3D Cell-Based Biosensors for Toxicity Testing, Disease Modeling and Optical/Electrical Stimulation of Cell Types Exploded view of the 3D MEA: 3D microtowers, metallization, laminate insulation and containment culture well with a close-up of 10 recording sites per patch. Fully functional for “disease in a... Read More

Figure 1. Schematic view of the imaging operational concept.

Cost-Effective Imaging System Uses RF Magnetic Field and Loop Bolometer Array to Produce MRI-Quality Images

33853 – New system can generate detailed images of internal body structures and identify defects embedded in electronic circuits UCF researchers have designed a new imaging system that captures detailed, 3D views of an object’s internal structures and is more affordable, compact and transportable than other systems. The invention is safe to use for both medical and scientific applications, since... Read More

Diagram (a) illustrates the new UCF 3D-printing technique used to produce 3D-printed porous scaffolds for cell culture. Image (b) shows the honeycomb design of scaffolds and the actual appearance of scaffolds with different processing routes after recovery from a gelatin bath. Recovered prints were immersed in cell culture media to reveal pore formation with the existence of bubbles inside the struts. Scale bars are 10mm.

3D-Printing Technique for Creating Biomaterial Structures with Tailored Hierarchical Porosity

33859 – Novel printing technique enables the production of custom porous 3D printed biomaterial scaffolds UCF researchers have developed a new 3D printing technique to produce biomaterial scaffolds with controlled porosity. This technique enables the design and production of 3D printed structures with pores throughout the scaffold, providing additional sites for seeded cells to adhere and grow. ... Read More

Prostate cancer C4-2B cells on different stiffness CA scaffolds. Mineralizationincreases with stiffness.

3D Biomaterial Scaffolds Mimic Tumor Microenvironment and Enable Drug Screening for Personalized Cancer Therapies

33849 – New 3D biomaterial scaffold enables testing of chemotherapies before administering to patients Researchers at UCF and the Mayo Clinic are developing a diagnostic tool for predicting patient outcome in response to a particular cancer treatment. The tool consists of biomaterial scaffolds that mimic the in vivo 3D structure of the tumor microenvironment and can be used as an in vitro platform... Read More

Diagnostic Kit Detects Pathogenic Microorganisms Based on Electric Signatures

33854 – Novel kit uses electrophysiology to help clinicians identify and effectively treat bacterial diseases in plants, animals and humans UCF researchers have developed a novel diagnostic kit for quickly identifying microorganisms and detecting live versus dead cells, based on their electrical activity. The invention can also be used to determine whether a cell is actively growing,... Read More

New Local Anesthetic Solution Minimizes Injection-Related Pain and Extends Limited Lidocaine Supplies

33832 – Improved Lidocaine Formulation Minimizes Pain at Injection Site While Maintaining Effectiveness Administered in more than 1 million cutaneous surgeries per year, local anesthesia injections are viewed as a very painful part of minor surgery. Additionally, the lidocaine for such formulations is in short supply. In response to these issues, UCF researchers have developed a new... Read More

UCF’s Young Adult and Adolescent Male Health Behavior Indicators Scale enables health organizations to gain deeper insight into the health-related attitudes, perceptions and experiences of YAAM populations and the health disparities that they encounter.

Assessment Tool Identifies Male Behavior and Attitudes Toward Healthcare

33783 – Survey Tool Enables Researchers to Capture Critical Data about Promoting Health Services to Young Adult Males UCF researchers have developed a valuable survey tool that can help organizations improve their healthcare service and delivery systems aimed at young adult and adolescent males (YAAMs). With the Young Adult and Adolescent Male Health Behavior Indicators Scale, health... Read More

Decision Support System Helps Hospitals Prevent Heart Failure Readmissions

33648 – Low-cost, innovative support tool enables care managers to implement interventions that prevent readmissions and improve the health outcomes of patients with heart failure UCF researchers have invented a decision support tool for enhancing patient care and reducing hospital readmissions related to heart failure (HF). The innovative support tool identifies and analyzes patient-centric human... Read More

Figure 1. Left image: Dotted red lines show the abdominal region boundaries on the left. Right image: A thin discontinuous muscle wall (dotted blue curve) separates VAT and SAT.

First Automated System to Quantify White and Brown Adipose Tissue at the Whole-Body, Body-Region and Organ Levels

33690 – Innovative system enables clinicians to better assess health risks of obese patients by accurately identifying and quantifying body fats UCF researchers have developed the first automated system to provide accurate, quantitative data regarding a person’s white and brown body fat (adipose tissue) levels. The innovation enables clinicians to better assess possible health issues and risks... Read More

A sample SterilEyes application for the donning/doffing of a hazmat suit.

Real-Time Crowd-Sourced Oversight of Protective Equipment Donning/Doffing

33444 – Crowd sourced review and certifying service enables healthcare workers to have their PPE donning/doffing techniques collectively observed and reviewed in real time UCF researchers have developed a system and methods that healthcare workers, firefighters and other first responders can use to ensure that they and colleagues worldwide properly don (put on) or doff (take off) personnel... Read More

Illustration of the system capturing and identifying contaminated areas in a mock medical procedure

System Monitors Medical Procedures to Detect Sterile Field Contamination

33396 – UCF researchers have developed an automated detection system aimed at helping to prevent and reduce the number of healthcare-associated infections (HAIs) contracted during medical procedures. The new System for Detecting Sterile Field Events tracks activity during training or an actual medical procedure and identifies actions (such as contact-related events) that violate the sterile field and... Read More

Mosquitoes feeding on the Passive Insect Surveillance Sensor Device

Low-Cost Device Catches, Kills and Identifies Vectors with Infectious Diseases

33502 – According to the World Health Organization, vector-borne diseases account for more than 17 percent of all infectious diseases, causing more than 1 million deaths annually. Confirmed cases of Dengue fever (DENV), Zika (ZIKV) or chikungunya (CHIKV) in the Americas over the past few years now pose a heightened risk for epidemics in the U. S., as well as in the traditional endemic areas like... Read More

Breakthrough Optical Blood Coagulation Monitor Provides Real-time Feedback

31064 – Life-saving device continuously checks a patient’s blood clotting status during and after surgery UCF researchers have developed a breakthrough early-detection system that helps detect life-threatening blood clots during and after a medical procedure. Conventional laboratory blood coagulation tests are time-intensive, requiring blood to be drawn, processed and analyzed. The UCF real-time... Read More

Targeting Oxidative Stress for Parkinson’s Disease Therapy

32897 – Adeno-Associated Virus (AAV) Vector-Mediated Knockdown of NADPH Oxidase1 (Nox1) Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the aggregation of α-synuclein proteins and the progressive loss of dopaminergic neurons. Oxidative stress is a major contributing factor in the pathogenesis of PD and has been linked to both α-synuclein aggregation and... Read More

Schematic representation of the fabrication and use of the ISE.

Ready-to-Use Paper Ion Sensor for On-Site Analysis

33425 – Ion-selective electrodes (ISEs) are highly important for ion detection. Paper-based ISEs are a simple, low cost, and disposable alternative to conventional solid-contact ISEs. However, widespread use of paper-based ISEs has been limited due to poor detection limits (in the micromolar range), reliability, and selectivity. UCF researchers have developed novel ultra-sensitive paper-based ISEs... Read More

Rapid, Cost-Effective Test for Mycobacteria

33286 – UCF researchers have discovered a rapid, cost-effective method to test samples for mycobacterial infection. This measurement can be obtained by assaying a biological sample from the subject, providing a more cost effective, less labor intensive testing process. Once a mycobacterium is identified, this method can be further used to monitor the infection after treatment with an antibiotic. ... Read More

The Dementia and Delirium Analysis Research Tool

33410 – An easy-to-use, accessible questionnaire that both clinicians and caregivers can use with dementia and delirium patients Currently, screenings for delirium and dementia are performed separately and administered by a trained professional. However, this process is inconvenient and time consuming for both the clinician and the patient, often leading to misdiagnoses in busy clinical settings... Read More

A schematic showing the mechanisms by which a NC coating can prevent osteolysis by scavenging free radicals, suppressing immune reaction locally and inhibiting corrosion, in accordance with an embodiment.

New Coating for Prosthetic Implants Helps to Reduce Inflammation and Bone Loss

33321 – UCF researchers have invented a cerium oxide based coating with anti-inflammatory/anti-oxidant properties that may delay or prevent osteolysis by reducing inflammation and the presence of free radicals while restoring the environment’s electrochemical balance. The American Academy of Orthopedic Surgeons has projected the number of annual primary total hip joint replacement surgeries to... Read More

Block diagram of the experiment used to determine the emission spectra of the samples

Technique for Tagging Therapeutically Relevant Compounds for Tracking and Evaluation Using Infrared Excitation Sources

31590 – Methods, apparatus and systems for doping cerium oxide and other therapeutically valuable nanoparticles with rare earth ions so that infrared light is absorbed and visible light is emitted through the process of up-conversion Nanoparticles are increasingly being used in the biological sciences for various therapeutic and research purposes. Nanoceria, for example, is a potentially powerful... Read More

(6A) Photographic image of a first solution of dextran coated nanoceria after ultrafiltration with an Amicon 30 K filter. (6B) Photographic image of a second solution of dextran coated nanoceria after the solution is concentrated using a 30K Centricon concentrator.

Polymer Coated Nanoparticles For Selective Cytoprotection

31194 – Methods, systems and compositions of a biocompatible nanoparticle wherein normal, non-transformed, healthy cells are protected from oxidative stress, radiation therapy and chemotherapy while cancer cells are provided no protection Current treatments for cancer such as radiation and chemotherapy utilize the effects of oxidative stress and other reactive oxygen species to kill off diseased... Read More

Synthesis of Polymer Coated Ceria Nanoparticles for Biomedical Applications

31005 – The composition and synthesis of a biodegradable polymer coated ceria oxide nanoparticle Cerium oxide (CeO) nanoparticles exhibit potent antioxidant properties, as well as other desirable therapeutic characteristics such as prolonging neuronal cell life and protecting cells against UV radiation. Current methods of ceria nanoparticle synthesis and coating are expensive and have little... Read More

Depiction of layered structure of skin and the attenuation of incident light on the skin by various phenomena such as absorption and scattering.

Non-Invasive Sensor for Determining Blood-Sugar Levels in Diabetics and Characterizing Materials

30733 – Integrated sensor characterizes optically dense materials by distinguishing the scattering and absorption coefficients of the materials from the incident light Non-invasive monitoring of various patients’ parameters, such as glucose concentrations, offers many advantages over invasive measurements. Patients could monitor themselves intermittently or continuously, without the need to... Read More

Timeline of exposure of a primary retinal neuron culture to treatment with cerium oxide nanoparticles

Protection of Mammalian Cells Through the Inhibition of Reactive Oxygen Species Utilizing Cerium Oxide Nanoparticles

30812 – A composition of ceria oxide nanoparticles and their biological applications for the protection of mammalian cells against reactive oxygen species, with additional specifications for the treatment of retinal neurons against light-induced degeneration. Light-induced retina degeneration and age-related macular degeneration (AMD) are two common medical conditions which lead to sight... Read More

Head mounted brain stimulation medical device

Brain Surgery: Improvement of Deep Brain Stimulation Methods, Systems, and Devices

30314 – Methods, systems, and devices for enhancing both efficacy and efficiency of Deep Brain Stimulation – electrical stimulation known to inhibit symptoms of neurological diseases, disorders, and the like, such as tremors in Parkinson’s disease; and to substantially reduce power demands for Deep Brain Stimulation. Deep Brain Stimulation (DBS) is a form of brain surgery used to treat several... Read More

Perspective view of a first preferred embodiment of the novel probe and receiver device for simultaneous acquisition of spatial and spectral OCT (SI-OCT)

Simultaneous Spatial Imaging and Spectral Sensing for the Diagnosis of Cervical and Skin Cancers

30450 – A probe that simultaneously performs optical coherence tomography (OCT) and spectral analysis using back reflected light The present invention provides a tunable source of low-coherence light to simultaneously conduct spatial imaging and spectral sensing for tissue diagnosis. It offers a real time three dimensional colposcopy diagnosis and the detailed guidance to physically biopsy... Read More

Component configuration of image acquisition with photoelectric collection of the signal

Non-invasive Device for Image Acquisition through Super Thin Multimode Fibers

30402 – Non-invasive method and apparatus for image acquisition through a multimode fiber An optical fiber is a glass or plastic fiber that carries light along its length. Optical fibers have been widely used in several imaging devices, such as endoscopes and borescopes, which are utilized in medical and industrial applications in order to capture images from spaces closed to direct vision. In the... Read More

Scheme showing microarrays of enzyme assisted probes

Fluorescent Detection of Nucleic Acid Sequences using Binary Probes System

32131 – This invention is a new enzyme-assisted detection system for analyzing nucleic acids with real-time fluorescent signal generation Detection of nucleic acid sequences is critical for disease diagnosis, drug development, biomedical research, and forensic testing. A nucleic acid reporter is commonly used for the detection of specific sequences. This reporter probe is labeled with a... Read More

Cerium oxide coated electrode with electronic circuit

Faster Detection of Free Radicals

30949 – A nanoceria based regenerative radical sensor for plasma testing, food quality control, or drug development UCF researchers have developed an electrochemical sensor for the measurement of free radicals, or materials that generate free radicals, in solution. Ideal for biomedical, pharmaceutical, or sensor companies, this sensor has a long lifetime with the option of multiple uses. With an... Read More

Full length (LIMK), constitutively active phosphomimic (LIMKCA), LIMdomain only (LIMKLD), and kinase-domain only (LIMKKD) LIMK1 constructs were cloned into the pCMV14 vector used for expression in RWPE1 cells

Inhibiting Proliferation and Metastasis of Cancer Cells

32194 – This discovery provides methods and compounds for decreasing the expression of LIMK1 and AurKA in cancer cells. Metastasis of tumor cells contributes to about 90% of cancer-related deaths. Proteins that regulate cell motility are attractive targets for cancer therapy because they can also play key roles in cell survival, proliferation, and migration. Lim kinase 1 (LIMK1) is a protein that... Read More

XPS and contact angle analysis of DETA monolayer on glass coverslips; (A) XPS survey spectra analysis of the DETA coverslip, (B) XPS high resolution spectrum of N1s peak on DETA coverslip, (C) XPS high resolution spectrum of Si2p peak on DETA coverslip, (D) contact angle image of water on a DETA coverslip

In vitro Method of Myelinating Isolated Motoneurons

31869 – This invention provides a method for co-culturing isolated motoneurons with Schwann cells in a chemically defined serum-free medium that supports the growth and myelination of the motoneurons. Demyelinating neurodegenerative diseases such as multiple sclerosis result from damage to the insulating myelin sheath surrounding motoneurons. Loss of this myelin sheath significantly impairs signal... Read More

Restoring Innate Defense Against HIV Infection: Inducing Endogenous Expression of Retrocyclin Antimicrobials

31689 – Novel approach to HIV therapy enables the body’s own innate defense mechanisms to prevent HIV infection UCF researchers have developed a technique that induces human cells to produce functional theta-defensins, which are known to inhibit infection by the human immunodeficiency virus (HIV), the virus that causes AIDS. Theta-defensins, such as retrocyclins, are endogenous antimicrobial... Read More

Non-invasive, Low Cost, Portable Glucose Monitoring System

31028 – Methods and apparatus for creating a portable noninvasive glucose monitoring system, which includes a sensing solution containing specially designed nanoparticles sensitive to very minute changes in glucose level. Diabetes mellitus is the sixth-leading cause of death in the U.S. It is a medical disorder characterized by persistent variable hyperglycemia (high blood sugar levels), resulting... Read More

An example of an ipsilateral and contralateral electrode lead configuration according to the present invention with a single implantable pulse generator

New Electrode Contact Improves Targeted Electrical Current Flow from Deep Brain Stimulation

32653 – The current technology for circular electrode contacts on implanted leads for deep brain stimulation (DBS) has a major limitation: the electronic current flow is also a annular outflow from the cathode ring to an adjacent anode ring on the same lead. Although this arrangement works when the electrode contact is centered in the target site, e.g., the subthalamic nucleus (STN), it doesn’t work... Read More

Flow chart that shows steps in an example method for forming functionalized particles, according to an example embodiment

Micro- and Nano-Scale Polymeric Particle Fabrication

33036 – By forming a polymer casing that can encapsulate nanoparticles to deliver them to specific locations in the human body based on the polymer spheres’ shape, researchers have developed a technology to advance biomedical treatment and diagnosis. This ability to produce polymeric particles with a size, shape, and composition that determines finely-tuned physiochemical properties is made more... Read More

Demonstration of lowered CT toxicity to cells in culture when the 25 cells are treated with geldanamycin (GA)

Compounds Inhibiting Cholera Toxin and Other Similar Bacterial Toxins

31366 – Bacterial toxins have been known to be primary mediators of a number of diseases both of the intestinal tract and of other organ systems. Some bacterial toxins are known as AB-type toxins, since they are composed of a catalytic A subunit and a cell binding B subunit. Examples of such AB-type toxins include cholera toxin (CT), the E.coli heat-labile toxin (LT) responsible for traveler’s... Read More

Schematic representation of polymer-coated nanoceria with different surface charges displaying cell internalization, discrete subcellular localization and toxicity profiles

Target Cancer Cells with Coated Nanoceria

33361 – UCF researchers have created a new weapon in the fight against cancer by coating nanoparticles of cerium oxide, nanoceria, with polymers to affect the localization of nanoceria within cells and modulate its toxicity based on pH, to fight cancer cells while protecting normal cells. Even in the presence of oxygen, many cancers preferentially obtain their energy by converting glucose into... Read More

Flow diagram of a preferred method of the invention

Method and Tools to Study Neuromuscular Junction

31152 – Nervous system diseases such as amyotrophic lateral sclerosis, multiple sclerosis, and spinal cord injuries are debilitating conditions which currently have no effective treatments. Model systems which can effectively represent both neurons and muscles as well as the interaction between them are needed so that diseases can be studied and drug candidates can be accurately evaluated. ... Read More

Display of a method of preparing a carbon fiber from a fiber component

An Environmentally Friendly Approach to Cost-Effectively Produce Oxidized Graphite and Prepare Carbon Fiber

32747 – Researchers at the University of Central Florida (UCF) have developed a scalable, environmentally friendly method to produce oxidized graphite. UCF’s oxidized graphite is water dispersible, which aids in the preparation of thin films, carbon fibers, and carbon nanotubes; has resistivities ranging from 50-8,000 Ω/cm2; and, most importantly, allows for easy conversion to graphene. Oxidized... Read More

A schematic diagram of a capillary ionic transistor

Capillary Ionic Transistor: Simple, Cost-Effective, One-Step Procedure

32918 – The Capillary Ionic Transistor (CIT) nanodevice provides control of ionic transport through the nanochannel by gate voltage for use by pharmaceutical companies, medical instruments companies, hospitals, research organizations, microelectromechanical systems companies, and the chemical industry. Nanofluidic devices such as ionic diodes and ionic transistors form key elements in ionic... Read More

ClpXP unfolds and degrades protein substrates. Proteins bearing a degradation peptide (red) are recognized by ClpX (blue), unfolded and processively translocated through the pore of ClpP (green) where degradation occurs. ATP hydrolysis provides the unfolding and translocation energy.

Cellular Depletion of Biomolecular Targets

32372 – Of the ~4,400 Escherichia coli (E. coli) open reading frames, roughly a third have not had their encoded protein functions experimentally verified. This collection of genes creates a significant black box in our understanding of fundamental cellular physiology, especially when considering those genes of unknown function that are essential for viability. Much of what is known about gene... Read More

Representation of a mobile phone and a fluorimeter of the portable spectrometer system generating and collecting an emission spectrum of a test strip with an unknown substance in accordance with the present invention.

Rapid Drug Identification Kit

32772 – For drug analysts, it is difficult to identify certain types of drugs. Additionally, the frequency of new drugs introduced is at an alarming rate and this enhances the problem faced by the drug analysts. To help the drug analysts in the field, there are many reagent kits available to identify certain drugs based on the color they generate when reacted with the reagents. However, the... Read More

Non-Aqueous Amino Acid Production

32954 – The nutraceuticals, fodder, and laboratory industries require different standards and specifications for the amino acids and small peptide chains used. However, current methodology cannot produce these materials at the same time to meet these different standards and specifications because they are produced by aqueous acid hydrolysis or enzymatic hydrolysis. Additionally, these processes are... Read More